DegronMD - Q96AW1(VOPP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P88S	TCGA-04-1648	OV	TCGA	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.0833
p.D121N	TCGA-19-5956	GBM	TCGA	PPYY	ITCH	116:119	Mutation rewiring degron network	0.2778
p.D121N	TCGA-W3-AA21	SKCM	TCGA	PPYY	ITCH	116:119	Mutation rewiring degron network	0.2778
p.D121N	DO13863	GBM	ICGC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.2778
p.D121N	DO51278	SKCM	ICGC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.2778
p.P89R	TCGA-77-6845	LUSC	TCGA	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.1111
p.E166K	TCGA-B5-A0JY	UCEC	TCGA	PPAY	ITCH	154:157	Mutation rewiring degron network	0.0833
p.E166K	TCGA-B5-A0JY	UCEC	TCGA	PPPY	ITCH	162:165	Mutation rewiring degron network	0.3056
p.E166K	TCGA-F5-6814	READ	TCGA	PPAY	ITCH	154:157	Mutation rewiring degron network	0.0833
p.E166K	TCGA-F5-6814	READ	TCGA	PPPY	ITCH	162:165	Mutation rewiring degron network	0.3056
p.P107S	TCGA-BF-AAP2	SKCM	TCGA	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.25
p.P107S	TCGA-BF-AAP2	SKCM	TCGA	PPYY	ITCH	116:119	Mutation rewiring degron network	0.0833
p.G108D	TCGA-BG-A0VZ	UCEC	TCGA	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.2222
p.G108D	TCGA-BG-A0VZ	UCEC	TCGA	PPYY	ITCH	116:119	Mutation rewiring degron network	0.1111
p.P88L	TCGA-D1-A167	UCEC	TCGA	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.0833
p.P153S	TCGA-D3-A51G	SKCM	TCGA	PPAY	ITCH	154:157	Mutation rewiring degron network	0.3056
p.P153S	TCGA-D3-A51G	SKCM	TCGA	PPPY	ITCH	162:165	Mutation rewiring degron network	0.0833
p.P89S	TCGA-DA-A95V	SKCM	TCGA	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.1111
p.A111D	TCGA-DI-A1BU	UCEC	TCGA	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.1389
p.A111D	TCGA-DI-A1BU	UCEC	TCGA	PPYY	ITCH	116:119	Mutation rewiring degron network	0.1944
p.T160M	TCGA-HU-A4H8	STAD	TCGA	PPAY	ITCH	154:157	Mutation rewiring degron network	0.25
p.T160M	TCGA-HU-A4H8	STAD	TCGA	PPPY	ITCH	162:165	Mutation rewiring degron network	0.2778
p.T160M	DO47869	STAD	ICGC	PPAY	ITCH	154:157	Mutation rewiring degron network	0.25
p.T160M	DO47869	STAD	ICGC	PPPY	ITCH	162:165	Mutation rewiring degron network	0.2778
p.T160M	ACH-000515	Lung Cancer	CCLE	PPAY	ITCH	154:157	Mutation rewiring degron network	0.25
p.T160M	ACH-000515	Lung Cancer	CCLE	PPPY	ITCH	162:165	Mutation rewiring degron network	0.2778
p.T160M	HCC-33	lung	COSMIC	PPAY	ITCH	154:157	Mutation rewiring degron network	0.25
p.T160M	HCC-33	lung	COSMIC	PPPY	ITCH	162:165	Mutation rewiring degron network	0.2778
p.P125Q	DO222436	BTCA	ICGC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.1667
p.N159S	DO227987	COCA	ICGC	PPAY	ITCH	154:157	Mutation rewiring degron network	0.2778
p.N159S	DO227987	COCA	ICGC	PPPY	ITCH	162:165	Mutation rewiring degron network	0.25
p.P104T	DO229041	LICA	ICGC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7031
p.P104T	DO229006	LICA	ICGC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7031
p.E99K	DO36556	READ	ICGC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7022
p.E99K	DO43041	UCEC	ICGC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7022
p.P87S	DO219478	SKCM	ICGC	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.0556
p.G106D	DO42368	UCEC	ICGC	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.2778
p.G106D	DO42368	UCEC	ICGC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.0556
p.P125S	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.1667
p.P125S	NCI-H1975	lung	COSMIC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.1667
p.R102G	SIDM01157	Other Solid Cancers	GDSC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.6457
p.R102G	SW954	vulva	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.6457
p.R93G	SW954	vulva	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.2222
p.M117V	BT-549	breast	COSMIC	PPYY	ITCH	116:119	Mutation altering degron motif	0.7208
p.V113I	CW-2	large intestine	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.0833
p.V113I	CW-2	large intestine	COSMIC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.25
p.R100G	SW954	vulva	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7568
p.T93M	HCC-33	lung	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.2222
p.V128I	CW-2	large intestine	COSMIC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.0833
p.V151I	LN-229	central nervous system	COSMIC	PPAY	ITCH	154:157	Mutation rewiring degron network	0.25
p.T158M	HCC-33	lung	COSMIC	PPAY	ITCH	154:157	Mutation rewiring degron network	0.3056
p.T158M	HCC-33	lung	COSMIC	PPPY	ITCH	162:165	Mutation rewiring degron network	0.2222
p.V166I	LN-229	central nervous system	COSMIC	PPAY	ITCH	154:157	Mutation rewiring degron network	0.0833
p.V166I	LN-229	central nervous system	COSMIC	PPPY	ITCH	162:165	Mutation rewiring degron network	0.3056
p.P116S	NCI-H1975	lung	COSMIC	PPYY	ITCH	116:119	Mutation altering degron motif	0.6752
p.T157M	HCC-33	lung	COSMIC	PPAY	ITCH	154:157	Mutation altering degron motif	0.7423
p.V101I	LN-229	central nervous system	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7076
p.P108S	NCI-H1975	lung	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.2222
p.P108S	NCI-H1975	lung	COSMIC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.1111
p.V127I	CW-2	large intestine	COSMIC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.1111
p.R99G	SW954	vulva	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7568
p.M125V	BT-549	breast	COSMIC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.1667
p.T151M	HCC-33	lung	COSMIC	PPAY	ITCH	154:157	Mutation rewiring degron network	0.25
p.V105I	LN-229	central nervous system	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.3056
p.T97M	HCC-33	lung	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7423
p.V121I	CW-2	large intestine	COSMIC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.2778
p.V159I	LN-229	central nervous system	COSMIC	PPAY	ITCH	154:157	Mutation rewiring degron network	0.2778
p.V159I	LN-229	central nervous system	COSMIC	PPPY	ITCH	162:165	Mutation rewiring degron network	0.25
p.P123S	NCI-H1975	lung	COSMIC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.2222
p.V168I	LN-229	central nervous system	COSMIC	PPPY	ITCH	162:165	Mutation rewiring degron network	0.25
p.V165I	LN-229	central nervous system	COSMIC	PPPY	ITCH	162:165	Mutation altering degron motif	0.7076
p.P122S	NCI-H1975	lung	COSMIC	PPYY	ITCH	116:119	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VOPP1

UniProt ID: Q96AW1

Entrez ID: 81552

Protein name: Vesicular, overexpressed in cancer, prosurvival protein 1 (EGFR-coamplified and overexpressed protein) (ECop) (Glioblastoma-amplified secreted protein) (Putative NF-kappa-B-activating protein 055N)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for VOPP1 in