DegronMD - Q96AW1(VOPP1)

FUNCTION: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. {ECO:0000269|PubMed:15735698}.

GO - Biological processes (BP):

GO - Molecular function (MF):

GO - Cellular component (CC): cytoplasmic vesicle membrane [GO:0030659]; endosome [GO:0005768]; integral component of organelle membrane [GO:0031301]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
NVSYTRQP	CBL_PTK	CBL	Vesicular, overexpressed in cancer, prosurvival protein 1	97:104	More..
PPYY	ITCH	ITCH,NEDD4	Vesicular, overexpressed in cancer, prosurvival protein 1	116:119	More..
PPAY	ITCH	ITCH,NEDD4	Vesicular, overexpressed in cancer, prosurvival protein 1	154:157	More..
PPPY	ITCH	ITCH,NEDD4	Vesicular, overexpressed in cancer, prosurvival protein 1	162:165	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R100G	SW954	vulva	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7568
p.R99G	SW954	vulva	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7568
p.T157M	HCC-33	lung	COSMIC	PPAY	ITCH	154:157	Mutation altering degron motif	0.7423
p.T97M	HCC-33	lung	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7423
p.M117V	BT-549	breast	COSMIC	PPYY	ITCH	116:119	Mutation altering degron motif	0.7208
p.V101I	LN-229	central nervous system	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7076
p.V165I	LN-229	central nervous system	COSMIC	PPPY	ITCH	162:165	Mutation altering degron motif	0.7076
p.P104T	DO229041	LICA	ICGC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7031
p.P104T	DO229006	LICA	ICGC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7031
p.E99K	DO36556	READ	ICGC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7022
p.E99K	DO43041	UCEC	ICGC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.7022
p.P116S	NCI-H1975	lung	COSMIC	PPYY	ITCH	116:119	Mutation altering degron motif	0.6752
p.R102G	SIDM01157	Other Solid Cancers	GDSC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.6457
p.R102G	SW954	vulva	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation altering degron motif	0.6457
p.E166K	TCGA-B5-A0JY	UCEC	TCGA	PPPY	ITCH	162:165	Mutation rewiring degron network	0.3056
p.E166K	TCGA-F5-6814	READ	TCGA	PPPY	ITCH	162:165	Mutation rewiring degron network	0.3056
p.P153S	TCGA-D3-A51G	SKCM	TCGA	PPAY	ITCH	154:157	Mutation rewiring degron network	0.3056
p.T158M	HCC-33	lung	COSMIC	PPAY	ITCH	154:157	Mutation rewiring degron network	0.3056
p.V166I	LN-229	central nervous system	COSMIC	PPPY	ITCH	162:165	Mutation rewiring degron network	0.3056
p.V105I	LN-229	central nervous system	COSMIC	NVSYTRQP	CBL_PTK	97:104	Mutation rewiring degron network	0.3056

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Kaplan plot for VOPP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VOPP1

UniProt ID: Q96AW1

Entrez ID: 81552

Protein name: Vesicular, overexpressed in cancer, prosurvival protein 1 (EGFR-coamplified and overexpressed protein) (ECop) (Glioblastoma-amplified secreted protein) (Putative NF-kappa-B-activating protein 055N)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VOPP1 in