DegronMD

Uniprot ID: Q96AW1

Source protein: Vesicular, overexpressed in cancer, prosurvival protein 1

Source gene: VOPP1

Class: ITCH

Location: 116:119

E3 ligase: ITCH,NEDD4

DEGRON score: 0.6737

ASA_SCORE: 69.125

COIL: 0.8253

CONS_SCORE: 0.6483

DSS_SCORE: 0.7476

HELIX: 0.0215

FCONS_SCORE: 1.0784

RIG_SCORE: 0.5934

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D121N	TCGA-19-5956	GBM	TCGA	PPYY	ITCH	0.2778
p.D121N	TCGA-W3-AA21	SKCM	TCGA	PPYY	ITCH	0.2778
p.D121N	DO13863	GBM	ICGC	PPYY	ITCH	0.2778
p.D121N	DO51278	SKCM	ICGC	PPYY	ITCH	0.2778
p.P107S	TCGA-BF-AAP2	SKCM	TCGA	PPYY	ITCH	0.0833
p.G108D	TCGA-BG-A0VZ	UCEC	TCGA	PPYY	ITCH	0.1111
p.A111D	TCGA-DI-A1BU	UCEC	TCGA	PPYY	ITCH	0.1944
p.P125Q	DO222436	BTCA	ICGC	PPYY	ITCH	0.1667
p.G106D	DO42368	UCEC	ICGC	PPYY	ITCH	0.0556
p.P125S	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	PPYY	ITCH	0.1667
p.P125S	NCI-H1975	lung	COSMIC	PPYY	ITCH	0.1667
p.M117V	BT-549	breast	COSMIC	PPYY	ITCH	0.7208
p.V113I	CW-2	large_intestine	COSMIC	PPYY	ITCH	0.25
p.V128I	CW-2	large_intestine	COSMIC	PPYY	ITCH	0.0833
p.P116S	NCI-H1975	lung	COSMIC	PPYY	ITCH	0.6752
p.P108S	NCI-H1975	lung	COSMIC	PPYY	ITCH	0.1111
p.V127I	CW-2	large_intestine	COSMIC	PPYY	ITCH	0.1111
p.M125V	BT-549	breast	COSMIC	PPYY	ITCH	0.1667
p.V121I	CW-2	large_intestine	COSMIC	PPYY	ITCH	0.2778
p.P123S	NCI-H1975	lung	COSMIC	PPYY	ITCH	0.2222
p.P122S	NCI-H1975	lung	COSMIC	PPYY	ITCH	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94915	Protein furry homolog-like	ITCH	1462:1465	PPYY	ITCH,NEDD4	0.9735	More...
P13611	Versican core protein	ITCH	2804:2807	PPYY	ITCH,NEDD4	0.882	More...
P13942	Collagen alpha-2	ITCH	277:280	PPYY	ITCH,NEDD4	0.9939	More...
P23771	Trans-acting T-cell-specific transcription factor GATA-3	ITCH	61:64	PPYY	ITCH,NEDD4	0.9955	More...
P37231	Peroxisome proliferator-activated receptor gamma	ITCH	113:116	PPYY	ITCH,NEDD4	0.5611	More...
P67809	Y-box-binding protein 1	ITCH	194:197	PPYY	ITCH,NEDD4	0.9958	More...
Q13310	Polyadenylate-binding protein 4	ITCH	420:423	PPYY	ITCH,NEDD4	0.9823	More...
Q6ZTQ4	Cadherin-related family member 3	ITCH	438:441	PPYY	ITCH,NEDD4	0.6494	More...
Q7Z7F0	KH homology domain-containing protein 4	ITCH	352:355	PPYY	ITCH,NEDD4	0.92	More...
Q96AW1	Vesicular, overexpressed in cancer, prosurvival protein 1	ITCH	116:119	PPYY	ITCH,NEDD4	0.6737	More...
Q99439	Calponin-2	ITCH	300:303	PPYY	ITCH,NEDD4	0.9844	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	834:837	PPYY	ITCH,NEDD4	0.9444	More...
Q9H040	DNA-dependent metalloprotease SPRTN	ITCH	177:180	PPYY	ITCH,NEDD4	0.7657	More...
Q9NRM1	Enamelin	ITCH	212:215	PPYY	ITCH,NEDD4	0.6712	More...
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	ITCH	254:257	PPYY	ITCH,NEDD4	0.5243	More...
Q9Y6H8	Gap junction alpha-3 protein	ITCH	269:272	PPYY	ITCH,NEDD4	0.9959	More...
P55808	Glycoprotein Xg	ITCH	50:53	PPYY	ITCH,NEDD4	0.8102	More...
Q5JSJ4	Integrator complex subunit 6-like	ITCH	424:427	PPYY	ITCH,NEDD4	0.9555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons