DegronMD - P37231(PPARG)

GO - Biological processes (BP): activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cell maturation [GO:0048469]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; epithelial cell differentiation [GO:0030855]; fatty acid metabolic process [GO:0006631]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; innate immune response [GO:0045087]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; lipoprotein transport [GO:0042953]; long-chain fatty acid transport [GO:0015909]; macrophage derived foam cell differentiation [GO:0010742]; monocyte differentiation [GO:0030224]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of connective tissue replacement involved in inflammatory response wound healing [GO:1904597]; negative regulation of gene expression [GO:0010629]; negative regulation of gene silencing by miRNA [GO:0060965]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interferon-gamma-mediated signaling pathway [GO:0060336]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; negative regulation of sequestering of triglyceride [GO:0010891]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; placenta development [GO:0001890]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of gene expression [GO:0010628]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; regulation of blood pressure [GO:0008217]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of cholesterol transporter activity [GO:0060694]; regulation of circadian rhythm [GO:0042752]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipid [GO:0033993]; response to nutrient [GO:0007584]; retinoic acid receptor signaling pathway [GO:0048384]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; white fat cell differentiation [GO:0050872] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R85K	TCGA-DA-A1HW	SKCM	TCGA	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.1667
p.P82A	TCGA-DK-AA71	BLCA	TCGA	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.25
p.P88A	TCGA-DU-7006	LGG	TCGA	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.0833
p.S117Y	TCGA-E6-A1LX	UCEC	TCGA	PPYY	ITCH	113:116	Mutation rewiring degron network	0.3056
p.E79K	TCGA-EW-A1IZ	BRCA	TCGA	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation altering degron motif	0.7022
p.E79K	TCGA-W3-AA1V	SKCM	TCGA	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation altering degron motif	0.7022
p.D68H	DO49800	BLCA	ICGC	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.1944
p.L69R	DO1118	BRCA	ICGC	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.2222
p.V80A	DO230312	COCA	ICGC	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.3056
p.R112H	DO234387	ESAD	ICGC	PPYY	ITCH	113:116	Mutation blocking phosphorylation signal	0.75
p.R112H	DO47869	STAD	ICGC	PPYY	ITCH	113:116	Mutation blocking phosphorylation signal	0.75
p.Y123C	DO50856	LICA	ICGC	PPYY	ITCH	113:116	Mutation rewiring degron network	0.1389
p.P85S	DO220857	MELA	ICGC	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.1667
p.G124R	DO220886	MELA	ICGC	PPYY	ITCH	113:116	Mutation rewiring degron network	0.1111
p.G120T	DO222875	MELA	ICGC	PPYY	ITCH	113:116	Mutation rewiring degron network	0.2222
p.S89Y	DO41020	UCEC	ICGC	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.0556
p.T67A	SIDM00367	Small Cell Lung Carcinoma	GDSC	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.1667
p.T67A	SBC-3	lung	COSMIC	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.1667
p.I81F	SIDM00761	Small Cell Lung Carcinoma	GDSC	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.2778
p.I81F	NCI-H196	lung	COSMIC	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.2778
p.S112C	SIDM00528	Breast Carcinoma	GDSC	PPYY	ITCH	113:116	Mutation blocking phosphorylation signal	0.75
p.S112C	MDA-MB-361	breast	COSMIC	PPYY	ITCH	113:116	Mutation blocking phosphorylation signal	0.75
p.S72G	SIDM01560	Rhabdomyosarcoma	GDSC	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.3056
p.D64Y	ACH-000201	Rhabdoid	CCLE	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.0833
p.D64Y	ACH-001212	Rhabdoid	CCLE	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.0833
p.S74C	ACH-000696	Ovarian Cancer	CCLE	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation altering degron motif	0.643
p.S84C	ACH-000934	Breast Cancer	CCLE	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.1944
p.S84C	MDA-MB-361	breast	COSMIC	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.1944
p.D64N	ACH-002338	Skin Cancer	CCLE	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.0833
p.D64N	ACH-002510	Skin Cancer	CCLE	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.0833
p.V68I	23132-87	stomach	COSMIC	ISTPHYE	DEG_SCF_FBW7_2	73:79	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPARG

UniProt ID: P37231

Entrez ID: 5468

Protein name: Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPARG in