DegronMD

Uniprot ID: P37231

Source protein: Peroxisome proliferator-activated receptor gamma

Source gene: PPARG

Class: ITCH

Location: 113:116

E3 ligase: ITCH,NEDD4

DEGRON score: 0.5611

ASA_SCORE: 86.4

COIL: 0.8528

CONS_SCORE: 0.447

DSS_SCORE: 0.3983

HELIX: 0.0855

FCONS_SCORE: 0.9934

RIG_SCORE: 0.6924

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S117Y	TCGA-E6-A1LX	UCEC	TCGA	PPYY	ITCH	0.3056
p.R112H	DO234387	ESAD	ICGC	PPYY	ITCH	0.75
p.R112H	DO47869	STAD	ICGC	PPYY	ITCH	0.75
p.Y123C	DO50856	LICA	ICGC	PPYY	ITCH	0.1389
p.G124R	DO220886	MELA	ICGC	PPYY	ITCH	0.1111
p.G120T	DO222875	MELA	ICGC	PPYY	ITCH	0.2222
p.S112C	SIDM00528	Breast Carcinoma	GDSC	PPYY	ITCH	0.75
p.S112C	MDA-MB-361	breast	COSMIC	PPYY	ITCH	0.75

Drug responses associated with PPARG mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01164	LGG\|glioma	p.A263V (No)	GDSC	FH535	5.4913
SIDM01164	LGG\|glioma	p.A263V (No)	GDSC	FH535	5.4913
SIDM01045	UCEC\|endometrium	p.L298fs*38 (No)	GDSC	FH535	2.9707
SIDM01045	UCEC\|endometrium	p.L298fs*38 (No)	GDSC	FH535	2.9707
SIDM00980	STAD\|stomach	p.V90I (No)	GDSC	FH535	3.642
SIDM00980	STAD\|stomach	p.V90I (No)	GDSC	FH535	3.642
SIDM00612	LGG\|glioma	p.I264M (No)	GDSC	FH535	23.4365
SIDM00612	LGG\|glioma	p.I264M (No)	GDSC	FH535	23.4365
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.S186fs*2 (No)	GDSC	FH535	19.962
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.S186fs*2 (No)	GDSC	FH535	19.962
SIDM00529	BRCA\|breast	p.V335L (No)	GDSC	FH535	6.986
SIDM00529	BRCA\|breast	p.V335L (No)	GDSC	FH535	6.986
SIDM00256	NB\|neuroblastoma	p.V48M (No)	GDSC	FH535	4.4189
SIDM00256	NB\|neuroblastoma	p.V48M (No)	GDSC	FH535	4.4189
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.E28K (No)	GDSC	FH535	6.5838
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.E28K (No)	GDSC	FH535	6.5838
SIDM01085	BLCA\|bladder	p.T475M (No)	GDSC	FH535	86.5513
SIDM01085	BLCA\|bladder	p.T475M (No)	GDSC	FH535	86.5513
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.E304K (No)	GDSC	FH535	6.8558
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.E304K (No)	GDSC	FH535	6.8558
SIDM00257	NB\|neuroblastoma	p.L480P (No)	GDSC	FH535	5.255
SIDM00257	NB\|neuroblastoma	p.L480P (No)	GDSC	FH535	5.255
SIDM00789	COREAD\|large_intestine	p.K450Q (No)	GDSC	FH535	6.3457
SIDM00789	COREAD\|large_intestine	p.K450Q (No)	GDSC	FH535	6.3457
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S370F (No)	GDSC	FH535	29.3362
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S370F (No)	GDSC	FH535	29.3362
SIDM01112	UNCLASSIFIED\|bone_other	p.V335L (No)	GDSC	FH535	5.9799
SIDM01112	UNCLASSIFIED\|bone_other	p.V335L (No)	GDSC	FH535	5.9799
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.L493P (No)	GDSC	FH535	5.3699
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.L493P (No)	GDSC	FH535	5.3699
SIDM00528	BRCA\|breast	p.S112C (Yes)	GDSC	FH535	2.7366
SIDM00528	BRCA\|breast	p.S112C (Yes)	GDSC	FH535	2.7366
SIDM00364	ALL\|lymphoblastic_leukemia	p.P255R (No)	GDSC	FH535	11.5572
SIDM00364	ALL\|lymphoblastic_leukemia	p.P255R (No)	GDSC	FH535	11.5572
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.V478L (No)	GDSC	FH535	3.8752
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.V478L (No)	GDSC	FH535	3.8752
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.I81F (No)	GDSC	FH535	32.4868
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.I81F (No)	GDSC	FH535	32.4868
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.T67A (No)	GDSC	FH535	0.5396
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.T67A (No)	GDSC	FH535	0.5396

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94915	Protein furry homolog-like	ITCH	1462:1465	PPYY	ITCH,NEDD4	0.9735	More...
P13611	Versican core protein	ITCH	2804:2807	PPYY	ITCH,NEDD4	0.882	More...
P13942	Collagen alpha-2	ITCH	277:280	PPYY	ITCH,NEDD4	0.9939	More...
P23771	Trans-acting T-cell-specific transcription factor GATA-3	ITCH	61:64	PPYY	ITCH,NEDD4	0.9955	More...
P37231	Peroxisome proliferator-activated receptor gamma	ITCH	113:116	PPYY	ITCH,NEDD4	0.5611	More...
P67809	Y-box-binding protein 1	ITCH	194:197	PPYY	ITCH,NEDD4	0.9958	More...
Q13310	Polyadenylate-binding protein 4	ITCH	420:423	PPYY	ITCH,NEDD4	0.9823	More...
Q6ZTQ4	Cadherin-related family member 3	ITCH	438:441	PPYY	ITCH,NEDD4	0.6494	More...
Q7Z7F0	KH homology domain-containing protein 4	ITCH	352:355	PPYY	ITCH,NEDD4	0.92	More...
Q96AW1	Vesicular, overexpressed in cancer, prosurvival protein 1	ITCH	116:119	PPYY	ITCH,NEDD4	0.6737	More...
Q99439	Calponin-2	ITCH	300:303	PPYY	ITCH,NEDD4	0.9844	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	834:837	PPYY	ITCH,NEDD4	0.9444	More...
Q9H040	DNA-dependent metalloprotease SPRTN	ITCH	177:180	PPYY	ITCH,NEDD4	0.7657	More...
Q9NRM1	Enamelin	ITCH	212:215	PPYY	ITCH,NEDD4	0.6712	More...
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	ITCH	254:257	PPYY	ITCH,NEDD4	0.5243	More...
Q9Y6H8	Gap junction alpha-3 protein	ITCH	269:272	PPYY	ITCH,NEDD4	0.9959	More...
P55808	Glycoprotein Xg	ITCH	50:53	PPYY	ITCH,NEDD4	0.8102	More...
Q5JSJ4	Integrator complex subunit 6-like	ITCH	424:427	PPYY	ITCH,NEDD4	0.9555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPYY

Degron related mutations and impact score

Drug responses associated with PPARG mutations

All proteins holding degron of PPYY