DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPYY
Uniprot ID:
P55808
Source protein:
Glycoprotein Xg
Source gene:
XG
Class:
ITCH
Location:
50:53
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.8102
ASA_SCORE:
87.95
COIL:
0.9435
CONS_SCORE:
0.8081
DSS_SCORE:
0.7964
HELIX:
0.0215
FCONS_SCORE:
0.9655
RIG_SCORE:
0.5717
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K47Q
TCGA-A5-A2K5
UCEC
TCGA
PPYY
ITCH
0.3611
p.K47Q
DO41379
UCEC
ICGC
PPYY
ITCH
0.3611
p.Y53F
TCGA-AA-A01P
COAD
TCGA
PPYY
ITCH
0.7528
p.Y53F
DO8642
COAD
ICGC
PPYY
ITCH
0.7528
p.S42L
TCGA-XF-A9SZ
BLCA
TCGA
PPYY
ITCH
0.1111
p.S42L
DO51919
BLCA
ICGC
PPYY
ITCH
0.1111
p.D60N
DO230550
LUSC
ICGC
PPYY
ITCH
0.1389
p.D60N
DO231049
LUSC
ICGC
PPYY
ITCH
0.1389
p.Y53H
DO231189
LUSC
ICGC
PPYY
ITCH
0.7229
p.P54T
DO35242
PACA
ICGC
PPYY
ITCH
0.3056
p.P51S
SIDM01059
Melanoma
GDSC
PPYY
ITCH
0.6752
p.P51S
ACH-000915
Skin Cancer
CCLE
PPYY
ITCH
0.6752
p.P51S
IPC-298
skin
COSMIC
PPYY
ITCH
0.6752
Drug responses associated with XG mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPYY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94915
Protein furry homolog-like
ITCH
1462:1465
PPYY
ITCH,NEDD4
0.9735
More...
P13611
Versican core protein
ITCH
2804:2807
PPYY
ITCH,NEDD4
0.882
More...
P13942
Collagen alpha-2
ITCH
277:280
PPYY
ITCH,NEDD4
0.9939
More...
P23771
Trans-acting T-cell-specific transcription factor GATA-3
ITCH
61:64
PPYY
ITCH,NEDD4
0.9955
More...
P37231
Peroxisome proliferator-activated receptor gamma
ITCH
113:116
PPYY
ITCH,NEDD4
0.5611
More...
P67809
Y-box-binding protein 1
ITCH
194:197
PPYY
ITCH,NEDD4
0.9958
More...
Q13310
Polyadenylate-binding protein 4
ITCH
420:423
PPYY
ITCH,NEDD4
0.9823
More...
Q6ZTQ4
Cadherin-related family member 3
ITCH
438:441
PPYY
ITCH,NEDD4
0.6494
More...
Q7Z7F0
KH homology domain-containing protein 4
ITCH
352:355
PPYY
ITCH,NEDD4
0.92
More...
Q96AW1
Vesicular, overexpressed in cancer, prosurvival protein 1
ITCH
116:119
PPYY
ITCH,NEDD4
0.6737
More...
Q99439
Calponin-2
ITCH
300:303
PPYY
ITCH,NEDD4
0.9844
More...
Q9BUJ2
Heterogeneous nuclear ribonucleoprotein U-like protein 1
ITCH
834:837
PPYY
ITCH,NEDD4
0.9444
More...
Q9H040
DNA-dependent metalloprotease SPRTN
ITCH
177:180
PPYY
ITCH,NEDD4
0.7657
More...
Q9NRM1
Enamelin
ITCH
212:215
PPYY
ITCH,NEDD4
0.6712
More...
Q9P0X4
Voltage-dependent T-type calcium channel subunit alpha-1I
ITCH
254:257
PPYY
ITCH,NEDD4
0.5243
More...
Q9Y6H8
Gap junction alpha-3 protein
ITCH
269:272
PPYY
ITCH,NEDD4
0.9959
More...
P55808
Glycoprotein Xg
ITCH
50:53
PPYY
ITCH,NEDD4
0.8102
More...
Q5JSJ4
Integrator complex subunit 6-like
ITCH
424:427
PPYY
ITCH,NEDD4
0.9555
More...