DegronMD - P13942(COL11A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G349E	TCGA-21-5783	LUSC	TCGA	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.2222
p.T269A	TCGA-A5-A0G1	UCEC	TCGA	PPYY	ITCH	277:280	Mutation rewiring degron network	0.1111
p.R293Q	TCGA-A5-A0GP	UCEC	TCGA	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.3056
p.E672K	TCGA-AA-3510	COAD	TCGA	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation rewiring degron network	0.3056
p.S279L	TCGA-AJ-A3EL	UCEC	TCGA	PPYY	ITCH	277:280	Mutation altering degron motif	0.7667
p.S279L	ACH-001616	Lymphoma	CCLE	PPYY	ITCH	277:280	Mutation altering degron motif	0.7667
p.P357H	TCGA-AX-A2HD	UCEC	TCGA	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.2778
p.V666M	TCGA-AZ-6601	COAD	TCGA	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation altering degron motif	0.7208
p.L350P	TCGA-CA-5796	COAD	TCGA	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.25
p.G294E	TCGA-DA-A3F5	SKCM	TCGA	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation altering degron motif	0.7199
p.S353L	TCGA-EE-A181	SKCM	TCGA	DYR	CBL_MET	353:355	Mutation altering degron motif	0.7667
p.G671S	TCGA-EE-A2MI	SKCM	TCGA	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation altering degron motif	0.6993
p.V675I	TCGA-EY-A1GU	UCEC	TCGA	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation rewiring degron network	0.2222
p.G297R	TCGA-GN-A4U7	SKCM	TCGA	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation altering degron motif	0.6457
p.R280T	DO465	BLCA	ICGC	PPYY	ITCH	277:280	Mutation altering degron motif	0.7876
p.Q292E	DO219727	CESC	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.2778
p.E309Q	DO51599	CESC	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.0556
p.E298K	DO222794	COCA	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation altering degron motif	0.591
p.E276K	DO222729	COCA	ICGC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.3056
p.E276K	DO230529	LUSC	ICGC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.3056
p.E276K	DO35549	PBCA	ICGC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.3056
p.P275H	DO233732	GACA	ICGC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.2778
p.R308C	DO233884	GACA	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.0833
p.G286E	DO13324	GBM	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.1111
p.G286E	DO13324	GBM	ICGC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.1667
p.G295W	DO12928	GBM	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation altering degron motif	0.7825
p.E281K	DO14393	HNSC	ICGC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.3056
p.Y279C	DO22237	LGG	ICGC	PPYY	ITCH	277:280	Mutation altering degron motif	0.5976
p.G360S	DO50970	LICA	ICGC	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.1944
p.H674Q	DO22854	LIHC	ICGC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation rewiring degron network	0.25
p.R669Q	DO52211	LIHC	ICGC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation altering degron motif	0.7329
p.A277S	DO23874	LUAD	ICGC	PPYY	ITCH	277:280	Mutation altering degron motif	0.7588
p.A277S	DO42472	UCEC	ICGC	PPYY	ITCH	277:280	Mutation altering degron motif	0.7588
p.P289T	DO224563	LUSC	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.1944
p.P289T	DO224563	LUSC	ICGC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.0833
p.R308L	DO26632	LUSC	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.0833
p.G363R	DO45482	LUSC	ICGC	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.1111
p.P353S	DO220851	MELA	ICGC	DYR	CBL_MET	353:355	Mutation altering degron motif	0.6752
p.G357E	DO220912	MELA	ICGC	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.2778
p.G357R	DO222632	MELA	ICGC	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.2778
p.H674Y	DO222653	MELA	ICGC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation rewiring degron network	0.25
p.G679D	DO222731	MELA	ICGC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation rewiring degron network	0.1111
p.G673D	DO222837	MELA	ICGC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation rewiring degron network	0.2778
p.P290F	DO222843	MELA	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.2222
p.P290F	DO222843	MELA	ICGC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.0556
p.Y279H	DO228738	PBCA	ICGC	PPYY	ITCH	277:280	Mutation altering degron motif	0.6118
p.I302M	DO46897	RECA	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.25
p.T276P	DO219871	SKCA	ICGC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.3056
p.D681N	DO37551	SKCM	ICGC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation rewiring degron network	0.0556
p.L307F	DO37758	SKCM	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.1111
p.P359L	DO37707	SKCM	ICGC	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.2222
p.D298N	DO37499	SKCM	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation altering degron motif	0.6932
p.D298N	DO38627	STAD	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation altering degron motif	0.6932
p.D298N	DO41572	UCEC	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation altering degron motif	0.6932
p.G667R	DO47542	SKCM	ICGC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation altering degron motif	0.6457
p.E344Q	DO51294	SKCM	ICGC	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.0833
p.T285M	DO38711	STAD	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.0833
p.T285M	DO38711	STAD	ICGC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.1944
p.T285M	DO42568	UCEC	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.0833
p.T285M	DO42568	UCEC	ICGC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.1944
p.D305N	DO51761	STAD	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.1667
p.E269G	DO229216	THCA	ICGC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.1111
p.S305L	DO41542	UCEC	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.1667
p.T295A	DO42472	UCEC	ICGC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation altering degron motif	0.7139
p.D278N	DO41331	UCEC	ICGC	PPYY	ITCH	277:280	Mutation altering degron motif	0.6932
p.R669W	DO43971	UCEC	ICGC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation altering degron motif	0.8634
p.P279T	SIDM01306	Colorectal Carcinoma	GDSC	PPYY	ITCH	277:280	Mutation altering degron motif	0.7031
p.R347Q	SIDM00057	Neuroblastoma	GDSC	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.1667
p.R347Q	SIDM01611	Endometrial Carcinoma	GDSC	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.1667
p.R347Q	ACH-000676	Brain Cancer	CCLE	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.1667
p.R347Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.1667
p.R347Q	ACH-002389	Neuroblastoma	CCLE	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.1667
p.R347Q	ACN	autonomic ganglia	COSMIC	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.1667
p.G343D	SIDM00190	Melanoma	GDSC	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.0556
p.G343D	CP66-MEL	skin	COSMIC	DYR	CBL_MET	353:355	Mutation rewiring degron network	0.0556
p.V304M	SIDM00527	Colorectal Carcinoma	GDSC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.1944
p.V304M	ACH-000935	Colon/Colorectal Cancer	CCLE	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.1944
p.V304M	MDST8	large intestine	COSMIC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.1944
p.E286K	ACH-000649	Kidney Cancer	CCLE	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.1111
p.E286K	ACH-000649	Kidney Cancer	CCLE	PPYY	ITCH	277:280	Mutation rewiring degron network	0.1667
p.P289L	ACH-000995	Leukemia	CCLE	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.1944
p.P289L	ACH-000995	Leukemia	CCLE	PPYY	ITCH	277:280	Mutation rewiring degron network	0.0833
p.P289L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.1944
p.P289L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.0833
p.T673P	CHL-1	skin	COSMIC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation rewiring degron network	0.2778
p.P279H	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	PPYY	ITCH	277:280	Mutation altering degron motif	0.7694
p.P279H	JIMT-1	breast	COSMIC	PPYY	ITCH	277:280	Mutation altering degron motif	0.7694
p.V283M	MDST8	large intestine	COSMIC	PPYY	ITCH	277:280	Mutation rewiring degron network	0.25
p.P660S	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation rewiring degron network	0.1667
p.P674S	SKN	soft tissue	COSMIC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation rewiring degron network	0.25
p.A300V	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.3056
p.A300V	SNU-1040	large intestine	COSMIC	PTPGEE	DEG_SCF_FBW7_2	294:299	Mutation rewiring degron network	0.3056
p.G661E	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation rewiring degron network	0.1944
p.G676W	EM-2	haematopoietic and lymphoid tissue	COSMIC	IGPHGE	LIG_APCC_ABBA_1	666:671	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL11A2

UniProt ID: P13942

Entrez ID: 1302

Protein name: Collagen alpha-2(XI) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL11A2 in