DegronMD

Uniprot ID: P13942

Source protein: Collagen alpha-2

Source gene: COL11A2

Class: DEG_SCF_FBW7_2

Location: 294:299

E3 ligase: FBXW7

DEGRON score: 0.9884

ASA_SCORE: 72.7333

COIL: 0.8235

CONS_SCORE: 0.2949

DSS_SCORE: 0.8557

HELIX: 0.1028

FCONS_SCORE: 1.1434

RIG_SCORE: 0.6628

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R293Q	TCGA-A5-A0GP	UCEC	TCGA	PTPGEE	DEG_SCF_FBW7_2	0.3056
p.G294E	TCGA-DA-A3F5	SKCM	TCGA	PTPGEE	DEG_SCF_FBW7_2	0.7199
p.G297R	TCGA-GN-A4U7	SKCM	TCGA	PTPGEE	DEG_SCF_FBW7_2	0.6457
p.Q292E	DO219727	CESC	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.2778
p.E309Q	DO51599	CESC	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.0556
p.E298K	DO222794	COCA	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.591
p.R308C	DO233884	GACA	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.0833
p.G286E	DO13324	GBM	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.1111
p.G295W	DO12928	GBM	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.7825
p.P289T	DO224563	LUSC	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.1944
p.R308L	DO26632	LUSC	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.0833
p.P290F	DO222843	MELA	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.2222
p.I302M	DO46897	RECA	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.25
p.L307F	DO37758	SKCM	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.1111
p.D298N	DO37499	SKCM	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.6932
p.D298N	DO38627	STAD	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.6932
p.D298N	DO41572	UCEC	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.6932
p.T285M	DO38711	STAD	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.0833
p.T285M	DO42568	UCEC	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.0833
p.D305N	DO51761	STAD	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.1667
p.S305L	DO41542	UCEC	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.1667
p.T295A	DO42472	UCEC	ICGC	PTPGEE	DEG_SCF_FBW7_2	0.7139
p.V304M	SIDM00527	Colorectal Carcinoma	GDSC	PTPGEE	DEG_SCF_FBW7_2	0.1944
p.V304M	ACH-000935	Colon/Colorectal Cancer	CCLE	PTPGEE	DEG_SCF_FBW7_2	0.1944
p.V304M	MDST8	large_intestine	COSMIC	PTPGEE	DEG_SCF_FBW7_2	0.1944
p.E286K	ACH-000649	Kidney Cancer	CCLE	PTPGEE	DEG_SCF_FBW7_2	0.1111
p.P289L	ACH-000995	Leukemia	CCLE	PTPGEE	DEG_SCF_FBW7_2	0.1944
p.P289L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGEE	DEG_SCF_FBW7_2	0.1944
p.A300V	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGEE	DEG_SCF_FBW7_2	0.3056
p.A300V	SNU-1040	large_intestine	COSMIC	PTPGEE	DEG_SCF_FBW7_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPGEE

Degron related mutations and impact score

Drug responses associated with COL11A2 mutations

All proteins holding degron of PTPGEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13942	Collagen alpha-2	DEG_SCF_FBW7_2	294:299	PTPGEE	FBXW7	0.9884	More...