DegronMD

Uniprot ID: P13942

Source protein: Collagen alpha-2

Source gene: COL11A2

Class: LIG_APCC_ABBA_1

Location: 666:671

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9524

ASA_SCORE: 70.3833

COIL: 0.9143

CONS_SCORE: 0.5505

DSS_SCORE: 0.9263

HELIX: 0.0183

FCONS_SCORE: 0.8538

RIG_SCORE: 0.5252

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E672K	TCGA-AA-3510	COAD	TCGA	IGPHGE	LIG_APCC_ABBA_1	0.3056
p.V666M	TCGA-AZ-6601	COAD	TCGA	IGPHGE	LIG_APCC_ABBA_1	0.7208
p.G671S	TCGA-EE-A2MI	SKCM	TCGA	IGPHGE	LIG_APCC_ABBA_1	0.6993
p.V675I	TCGA-EY-A1GU	UCEC	TCGA	IGPHGE	LIG_APCC_ABBA_1	0.2222
p.H674Q	DO22854	LIHC	ICGC	IGPHGE	LIG_APCC_ABBA_1	0.25
p.R669Q	DO52211	LIHC	ICGC	IGPHGE	LIG_APCC_ABBA_1	0.7329
p.H674Y	DO222653	MELA	ICGC	IGPHGE	LIG_APCC_ABBA_1	0.25
p.G679D	DO222731	MELA	ICGC	IGPHGE	LIG_APCC_ABBA_1	0.1111
p.G673D	DO222837	MELA	ICGC	IGPHGE	LIG_APCC_ABBA_1	0.2778
p.D681N	DO37551	SKCM	ICGC	IGPHGE	LIG_APCC_ABBA_1	0.0556
p.G667R	DO47542	SKCM	ICGC	IGPHGE	LIG_APCC_ABBA_1	0.6457
p.R669W	DO43971	UCEC	ICGC	IGPHGE	LIG_APCC_ABBA_1	0.8634
p.T673P	CHL-1	skin	COSMIC	IGPHGE	LIG_APCC_ABBA_1	0.2778
p.P660S	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	IGPHGE	LIG_APCC_ABBA_1	0.1667
p.P674S	SKN	soft_tissue	COSMIC	IGPHGE	LIG_APCC_ABBA_1	0.25
p.G661E	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	IGPHGE	LIG_APCC_ABBA_1	0.1944
p.G676W	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	IGPHGE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13942	Collagen alpha-2	LIG_APCC_ABBA_1	666:671	IGPHGE	APC,CDC20,FZR1	0.9524	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons