DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPYY
Uniprot ID:
P13942
Source protein:
Collagen alpha-2
Source gene:
COL11A2
Class:
ITCH
Location:
277:280
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9939
ASA_SCORE:
80.975
COIL:
0.8175
CONS_SCORE:
0.2111
DSS_SCORE:
0.6207
HELIX:
0.0348
FCONS_SCORE:
0.962
RIG_SCORE:
0.7335
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T269A
TCGA-A5-A0G1
UCEC
TCGA
PPYY
ITCH
0.1111
p.S279L
TCGA-AJ-A3EL
UCEC
TCGA
PPYY
ITCH
0.7667
p.S279L
ACH-001616
Lymphoma
CCLE
PPYY
ITCH
0.7667
p.R280T
DO465
BLCA
ICGC
PPYY
ITCH
0.7876
p.E276K
DO222729
COCA
ICGC
PPYY
ITCH
0.3056
p.E276K
DO230529
LUSC
ICGC
PPYY
ITCH
0.3056
p.E276K
DO35549
PBCA
ICGC
PPYY
ITCH
0.3056
p.P275H
DO233732
GACA
ICGC
PPYY
ITCH
0.2778
p.G286E
DO13324
GBM
ICGC
PPYY
ITCH
0.1667
p.E281K
DO14393
HNSC
ICGC
PPYY
ITCH
0.3056
p.Y279C
DO22237
LGG
ICGC
PPYY
ITCH
0.5976
p.A277S
DO23874
LUAD
ICGC
PPYY
ITCH
0.7588
p.A277S
DO42472
UCEC
ICGC
PPYY
ITCH
0.7588
p.P289T
DO224563
LUSC
ICGC
PPYY
ITCH
0.0833
p.P290F
DO222843
MELA
ICGC
PPYY
ITCH
0.0556
p.Y279H
DO228738
PBCA
ICGC
PPYY
ITCH
0.6118
p.T276P
DO219871
SKCA
ICGC
PPYY
ITCH
0.3056
p.T285M
DO38711
STAD
ICGC
PPYY
ITCH
0.1944
p.T285M
DO42568
UCEC
ICGC
PPYY
ITCH
0.1944
p.E269G
DO229216
THCA
ICGC
PPYY
ITCH
0.1111
p.D278N
DO41331
UCEC
ICGC
PPYY
ITCH
0.6932
p.P279T
SIDM01306
Colorectal Carcinoma
GDSC
PPYY
ITCH
0.7031
p.E286K
ACH-000649
Kidney Cancer
CCLE
PPYY
ITCH
0.1667
p.P289L
ACH-000995
Leukemia
CCLE
PPYY
ITCH
0.0833
p.P289L
Jurkat
haematopoietic_and_lymphoid_tissue
COSMIC
PPYY
ITCH
0.0833
p.P279H
CRO-AP2
haematopoietic_and_lymphoid_tissue
COSMIC
PPYY
ITCH
0.7694
p.P279H
JIMT-1
breast
COSMIC
PPYY
ITCH
0.7694
p.V283M
MDST8
large_intestine
COSMIC
PPYY
ITCH
0.25
Drug responses associated with COL11A2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPYY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94915
Protein furry homolog-like
ITCH
1462:1465
PPYY
ITCH,NEDD4
0.9735
More...
P13611
Versican core protein
ITCH
2804:2807
PPYY
ITCH,NEDD4
0.882
More...
P13942
Collagen alpha-2
ITCH
277:280
PPYY
ITCH,NEDD4
0.9939
More...
P23771
Trans-acting T-cell-specific transcription factor GATA-3
ITCH
61:64
PPYY
ITCH,NEDD4
0.9955
More...
P37231
Peroxisome proliferator-activated receptor gamma
ITCH
113:116
PPYY
ITCH,NEDD4
0.5611
More...
P67809
Y-box-binding protein 1
ITCH
194:197
PPYY
ITCH,NEDD4
0.9958
More...
Q13310
Polyadenylate-binding protein 4
ITCH
420:423
PPYY
ITCH,NEDD4
0.9823
More...
Q6ZTQ4
Cadherin-related family member 3
ITCH
438:441
PPYY
ITCH,NEDD4
0.6494
More...
Q7Z7F0
KH homology domain-containing protein 4
ITCH
352:355
PPYY
ITCH,NEDD4
0.92
More...
Q96AW1
Vesicular, overexpressed in cancer, prosurvival protein 1
ITCH
116:119
PPYY
ITCH,NEDD4
0.6737
More...
Q99439
Calponin-2
ITCH
300:303
PPYY
ITCH,NEDD4
0.9844
More...
Q9BUJ2
Heterogeneous nuclear ribonucleoprotein U-like protein 1
ITCH
834:837
PPYY
ITCH,NEDD4
0.9444
More...
Q9H040
DNA-dependent metalloprotease SPRTN
ITCH
177:180
PPYY
ITCH,NEDD4
0.7657
More...
Q9NRM1
Enamelin
ITCH
212:215
PPYY
ITCH,NEDD4
0.6712
More...
Q9P0X4
Voltage-dependent T-type calcium channel subunit alpha-1I
ITCH
254:257
PPYY
ITCH,NEDD4
0.5243
More...
Q9Y6H8
Gap junction alpha-3 protein
ITCH
269:272
PPYY
ITCH,NEDD4
0.9959
More...
P55808
Glycoprotein Xg
ITCH
50:53
PPYY
ITCH,NEDD4
0.8102
More...
Q5JSJ4
Integrator complex subunit 6-like
ITCH
424:427
PPYY
ITCH,NEDD4
0.9555
More...
