DegronMD - P55808(XG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K47Q	TCGA-A5-A2K5	UCEC	TCGA	PPYY	ITCH	50:53	Mutation substituting flanking lysine	0.3611
p.K47Q	DO41379	UCEC	ICGC	PPYY	ITCH	50:53	Mutation substituting flanking lysine	0.3611
p.Y53F	TCGA-AA-A01P	COAD	TCGA	PPYY	ITCH	50:53	Mutation altering degron motif	0.7528
p.Y53F	DO8642	COAD	ICGC	PPYY	ITCH	50:53	Mutation altering degron motif	0.7528
p.S42L	TCGA-XF-A9SZ	BLCA	TCGA	PPYY	ITCH	50:53	Mutation rewiring degron network	0.1111
p.S42L	DO51919	BLCA	ICGC	PPYY	ITCH	50:53	Mutation rewiring degron network	0.1111
p.D60N	DO230550	LUSC	ICGC	PPYY	ITCH	50:53	Mutation rewiring degron network	0.1389
p.D60N	DO231049	LUSC	ICGC	PPYY	ITCH	50:53	Mutation rewiring degron network	0.1389
p.Y53H	DO231189	LUSC	ICGC	PPYY	ITCH	50:53	Mutation altering degron motif	0.7229
p.P54T	DO35242	PACA	ICGC	PPYY	ITCH	50:53	Mutation rewiring degron network	0.3056
p.P51S	SIDM01059	Melanoma	GDSC	PPYY	ITCH	50:53	Mutation altering degron motif	0.6752
p.P51S	ACH-000915	Skin Cancer	CCLE	PPYY	ITCH	50:53	Mutation altering degron motif	0.6752
p.P51S	IPC-298	skin	COSMIC	PPYY	ITCH	50:53	Mutation altering degron motif	0.6752

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons