DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPYY
Uniprot ID:
Q6ZTQ4
Source protein:
Cadherin-related family member 3
Source gene:
CDHR3
Class:
ITCH
Location:
438:441
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.6494
ASA_SCORE:
86.425
COIL:
0.853
CONS_SCORE:
0.7403
DSS_SCORE:
0.0313
HELIX:
0.008
FCONS_SCORE:
1.1633
RIG_SCORE:
0.841
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V447F
TCGA-86-8281
LUAD
TCGA
PPYY
ITCH
0.1667
p.T428M
TCGA-B5-A11N
UCEC
TCGA
PPYY
ITCH
0.0556
p.Y446H
TCGA-B5-A1MX
UCEC
TCGA
PPYY
ITCH
0.1944
p.V445I
TCGA-EO-A22T
UCEC
TCGA
PPYY
ITCH
0.2222
p.L450I
SIDM00683
Prostate Carcinoma
GDSC
PPYY
ITCH
0.0833
p.L450I
ACH-000977
lymph_node
CCLE
PPYY
ITCH
0.0833
p.L450I
LNCaP-Clone-FGC
prostate
COSMIC
PPYY
ITCH
0.0833
p.V447I
SIDM01011
B-Cell Non-Hodgkin's Lymphoma
GDSC
PPYY
ITCH
0.1667
p.A437G
SIDM00045
Gastric Carcinoma
GDSC
PPYY
ITCH
0.3056
p.G431R
MDA-MB-436
breast
COSMIC
PPYY
ITCH
0.1389
Drug responses associated with CDHR3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPYY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94915
Protein furry homolog-like
ITCH
1462:1465
PPYY
ITCH,NEDD4
0.9735
More...
P13611
Versican core protein
ITCH
2804:2807
PPYY
ITCH,NEDD4
0.882
More...
P13942
Collagen alpha-2
ITCH
277:280
PPYY
ITCH,NEDD4
0.9939
More...
P23771
Trans-acting T-cell-specific transcription factor GATA-3
ITCH
61:64
PPYY
ITCH,NEDD4
0.9955
More...
P37231
Peroxisome proliferator-activated receptor gamma
ITCH
113:116
PPYY
ITCH,NEDD4
0.5611
More...
P67809
Y-box-binding protein 1
ITCH
194:197
PPYY
ITCH,NEDD4
0.9958
More...
Q13310
Polyadenylate-binding protein 4
ITCH
420:423
PPYY
ITCH,NEDD4
0.9823
More...
Q6ZTQ4
Cadherin-related family member 3
ITCH
438:441
PPYY
ITCH,NEDD4
0.6494
More...
Q7Z7F0
KH homology domain-containing protein 4
ITCH
352:355
PPYY
ITCH,NEDD4
0.92
More...
Q96AW1
Vesicular, overexpressed in cancer, prosurvival protein 1
ITCH
116:119
PPYY
ITCH,NEDD4
0.6737
More...
Q99439
Calponin-2
ITCH
300:303
PPYY
ITCH,NEDD4
0.9844
More...
Q9BUJ2
Heterogeneous nuclear ribonucleoprotein U-like protein 1
ITCH
834:837
PPYY
ITCH,NEDD4
0.9444
More...
Q9H040
DNA-dependent metalloprotease SPRTN
ITCH
177:180
PPYY
ITCH,NEDD4
0.7657
More...
Q9NRM1
Enamelin
ITCH
212:215
PPYY
ITCH,NEDD4
0.6712
More...
Q9P0X4
Voltage-dependent T-type calcium channel subunit alpha-1I
ITCH
254:257
PPYY
ITCH,NEDD4
0.5243
More...
Q9Y6H8
Gap junction alpha-3 protein
ITCH
269:272
PPYY
ITCH,NEDD4
0.9959
More...
P55808
Glycoprotein Xg
ITCH
50:53
PPYY
ITCH,NEDD4
0.8102
More...
Q5JSJ4
Integrator complex subunit 6-like
ITCH
424:427
PPYY
ITCH,NEDD4
0.9555
More...