DegronMD

Uniprot ID: Q9BUJ2

Source protein: Heterogeneous nuclear ribonucleoprotein U-like protein 1

Source gene: HNRNPUL1

Class: ITCH

Location: 834:837

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9444

ASA_SCORE: 68.05

COIL: 0.898

CONS_SCORE: 0.3176

DSS_SCORE: 0.3341

HELIX: 0.0275

FCONS_SCORE: 0.9472

RIG_SCORE: 0.7865

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P834L	TCGA-B5-A3FC	UCEC	TCGA	PPYY	ITCH	0.7582
p.N824S	SIDM00845	Burkitt's Lymphoma	GDSC	PPYY	ITCH	0.0556
p.G831S	SIDM00845	Burkitt's Lymphoma	GDSC	PPYY	ITCH	0.25
p.Q825K	SIDM00670	Pancreatic Carcinoma	GDSC	PPYY	ITCH	0.0833
p.Q825K	HPAC	pancreas	COSMIC	PPYY	ITCH	0.0833
p.Y836H	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPYY	ITCH	0.6118
p.Y836H	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PPYY	ITCH	0.6118
p.G847R	ACH-002065	Sarcoma	CCLE	PPYY	ITCH	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94915	Protein furry homolog-like	ITCH	1462:1465	PPYY	ITCH,NEDD4	0.9735	More...
P13611	Versican core protein	ITCH	2804:2807	PPYY	ITCH,NEDD4	0.882	More...
P13942	Collagen alpha-2	ITCH	277:280	PPYY	ITCH,NEDD4	0.9939	More...
P23771	Trans-acting T-cell-specific transcription factor GATA-3	ITCH	61:64	PPYY	ITCH,NEDD4	0.9955	More...
P37231	Peroxisome proliferator-activated receptor gamma	ITCH	113:116	PPYY	ITCH,NEDD4	0.5611	More...
P67809	Y-box-binding protein 1	ITCH	194:197	PPYY	ITCH,NEDD4	0.9958	More...
Q13310	Polyadenylate-binding protein 4	ITCH	420:423	PPYY	ITCH,NEDD4	0.9823	More...
Q6ZTQ4	Cadherin-related family member 3	ITCH	438:441	PPYY	ITCH,NEDD4	0.6494	More...
Q7Z7F0	KH homology domain-containing protein 4	ITCH	352:355	PPYY	ITCH,NEDD4	0.92	More...
Q96AW1	Vesicular, overexpressed in cancer, prosurvival protein 1	ITCH	116:119	PPYY	ITCH,NEDD4	0.6737	More...
Q99439	Calponin-2	ITCH	300:303	PPYY	ITCH,NEDD4	0.9844	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	834:837	PPYY	ITCH,NEDD4	0.9444	More...
Q9H040	DNA-dependent metalloprotease SPRTN	ITCH	177:180	PPYY	ITCH,NEDD4	0.7657	More...
Q9NRM1	Enamelin	ITCH	212:215	PPYY	ITCH,NEDD4	0.6712	More...
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	ITCH	254:257	PPYY	ITCH,NEDD4	0.5243	More...
Q9Y6H8	Gap junction alpha-3 protein	ITCH	269:272	PPYY	ITCH,NEDD4	0.9959	More...
P55808	Glycoprotein Xg	ITCH	50:53	PPYY	ITCH,NEDD4	0.8102	More...
Q5JSJ4	Integrator complex subunit 6-like	ITCH	424:427	PPYY	ITCH,NEDD4	0.9555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons