DegronMD - Q7Z7F0(KHDC4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V348I	SIDM00845	Burkitt's Lymphoma	GDSC	PPYY	ITCH	352:355	Mutation rewiring degron network	0.2222
p.V348I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPYY	ITCH	352:355	Mutation rewiring degron network	0.2222
p.V348I	SIDM01519	Head and Neck Carcinoma	GDSC	PPYY	ITCH	352:355	Mutation rewiring degron network	0.2222
p.E513D	SIDM00589	Oral Cavity Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.25
p.E513D	HSC-3	upper aerodigestive tract	COSMIC	PASSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.25
p.R518G	SIDM00142	Endometrial Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1111
p.R518G	COLO-684	endometrium	COSMIC	PASSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1111
p.E513G	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.25
p.E513G	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.25
p.R516G	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1667
p.Q361L	SIDM01503	Small Cell Lung Carcinoma	GDSC	PPYY	ITCH	352:355	Mutation rewiring degron network	0.1667
p.D517H	EW-22	bone	COSMIC	PASSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1389
p.T358I	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PPYY	ITCH	352:355	Mutation rewiring degron network	0.25
p.S357G	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPYY	ITCH	352:355	Mutation rewiring degron network	0.2778
p.T342A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPYY	ITCH	352:355	Mutation rewiring degron network	0.0556

Kaplan plot for KHDC4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KHDC4

UniProt ID: Q7Z7F0

Entrez ID: 22889

Protein name: KH homology domain-containing protein 4 (Brings lots of money 7) (Pre-mRNA splicing factor protein KHDC4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KHDC4 in