DegronMD

Uniprot ID: Q9H040

Source protein: DNA-dependent metalloprotease SPRTN

Source gene: SPRTN

Class: ITCH

Location: 177:180

E3 ligase: ITCH,NEDD4

DEGRON score: 0.7657

ASA_SCORE: 84.875

COIL: 0.8423

CONS_SCORE: 0.6694

DSS_SCORE: 0.2297

HELIX: 0.0818

FCONS_SCORE: 0.8602

RIG_SCORE: 0.7774

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P172L	TCGA-78-7154	LUAD	TCGA	PPYY	ITCH	0.1944
p.P172L	DO24070	LUAD	ICGC	PPYY	ITCH	0.1944
p.R168C	TCGA-A7-A2KD	BRCA	TCGA	PPYY	ITCH	0.0833
p.R168C	DO3083	BRCA	ICGC	PPYY	ITCH	0.0833
p.R168C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPYY	ITCH	0.0833
p.R168C	ACH-000953	Leukemia	CCLE	PPYY	ITCH	0.0833
p.R168C	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PPYY	ITCH	0.0833
p.G181S	TCGA-A8-A09Z	BRCA	TCGA	PPYY	ITCH	0.3056
p.G181S	DO5521	BRCA	ICGC	PPYY	ITCH	0.3056
p.P178L	TCGA-AX-A2HG	UCEC	TCGA	PPYY	ITCH	0.7582
p.N170S	TCGA-HU-8249	STAD	TCGA	PPYY	ITCH	0.1389
p.N170S	DO47845	STAD	ICGC	PPYY	ITCH	0.1389
p.G179D	DO9876	COAD	ICGC	PPYY	ITCH	0.7198
p.K187Q	DO36556	READ	ICGC	PPYY	ITCH	0.1389
p.R189W	SIDM00422	Hodgkin's Lymphoma	GDSC	PPYY	ITCH	0.0833
p.R189W	ACH-001203	Lymphoma	CCLE	PPYY	ITCH	0.0833
p.R189W	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	PPYY	ITCH	0.0833
p.T187A	SIDM00435	Acute Myeloid Leukemia	GDSC	PPYY	ITCH	0.1389
p.T187A	SIDM01619	Endometrial Carcinoma	GDSC	PPYY	ITCH	0.1389
p.T187A	ACH-000369	Leukemia	CCLE	PPYY	ITCH	0.1389
p.T187A	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPYY	ITCH	0.1389
p.T187A	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	PPYY	ITCH	0.1389
p.E190K	SIDM00270	Head and Neck Carcinoma	GDSC	PPYY	ITCH	0.0556
p.E190K	ACH-001035	Bone Cancer	CCLE	PPYY	ITCH	0.0556
p.E190K	ACH-002294	Head and Neck Cancer	CCLE	PPYY	ITCH	0.0556
p.E190K	PCI-15A	upper_aerodigestive_tract	COSMIC	PPYY	ITCH	0.0556
p.G181R	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPYY	ITCH	0.3056
p.G181R	ACH-000697	Lymphoma	CCLE	PPYY	ITCH	0.3056
p.G181R	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	PPYY	ITCH	0.3056
p.R168H	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPYY	ITCH	0.0833
p.Y182C	SIDM00350	Head and Neck Carcinoma	GDSC	PPYY	ITCH	0.2778
p.Y182C	ACH-001641	Head and Neck Cancer	CCLE	PPYY	ITCH	0.2778
p.Y182C	SAT	upper_aerodigestive_tract	COSMIC	PPYY	ITCH	0.2778
p.E173D	SNU-81	large_intestine	COSMIC	PPYY	ITCH	0.2222
p.L185I	NB13	autonomic_ganglia	COSMIC	PPYY	ITCH	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94915	Protein furry homolog-like	ITCH	1462:1465	PPYY	ITCH,NEDD4	0.9735	More...
P13611	Versican core protein	ITCH	2804:2807	PPYY	ITCH,NEDD4	0.882	More...
P13942	Collagen alpha-2	ITCH	277:280	PPYY	ITCH,NEDD4	0.9939	More...
P23771	Trans-acting T-cell-specific transcription factor GATA-3	ITCH	61:64	PPYY	ITCH,NEDD4	0.9955	More...
P37231	Peroxisome proliferator-activated receptor gamma	ITCH	113:116	PPYY	ITCH,NEDD4	0.5611	More...
P67809	Y-box-binding protein 1	ITCH	194:197	PPYY	ITCH,NEDD4	0.9958	More...
Q13310	Polyadenylate-binding protein 4	ITCH	420:423	PPYY	ITCH,NEDD4	0.9823	More...
Q6ZTQ4	Cadherin-related family member 3	ITCH	438:441	PPYY	ITCH,NEDD4	0.6494	More...
Q7Z7F0	KH homology domain-containing protein 4	ITCH	352:355	PPYY	ITCH,NEDD4	0.92	More...
Q96AW1	Vesicular, overexpressed in cancer, prosurvival protein 1	ITCH	116:119	PPYY	ITCH,NEDD4	0.6737	More...
Q99439	Calponin-2	ITCH	300:303	PPYY	ITCH,NEDD4	0.9844	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	834:837	PPYY	ITCH,NEDD4	0.9444	More...
Q9H040	DNA-dependent metalloprotease SPRTN	ITCH	177:180	PPYY	ITCH,NEDD4	0.7657	More...
Q9NRM1	Enamelin	ITCH	212:215	PPYY	ITCH,NEDD4	0.6712	More...
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	ITCH	254:257	PPYY	ITCH,NEDD4	0.5243	More...
Q9Y6H8	Gap junction alpha-3 protein	ITCH	269:272	PPYY	ITCH,NEDD4	0.9959	More...
P55808	Glycoprotein Xg	ITCH	50:53	PPYY	ITCH,NEDD4	0.8102	More...
Q5JSJ4	Integrator complex subunit 6-like	ITCH	424:427	PPYY	ITCH,NEDD4	0.9555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPYY

Degron related mutations and impact score

Drug responses associated with SPRTN mutations

All proteins holding degron of PPYY