DegronMD - Q9BUJ2(HNRNPUL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P779A	TCGA-14-0866	GBM	TCGA	PPAY	ITCH	781:784	Mutation rewiring degron network	0.2778
p.P811S	TCGA-2W-A8YY	CESC	TCGA	NPAPYTPPP	CBL_PTK	793:801	Mutation rewiring degron network	0.0556
p.R721Q	TCGA-AZ-4615	COAD	TCGA	PPSY	ITCH	714:717	Mutation rewiring degron network	0.2222
p.P776R	TCGA-B0-5080	KIRC	TCGA	PPAY	ITCH	781:784	Mutation rewiring degron network	0.1944
p.P834L	TCGA-B5-A3FC	UCEC	TCGA	PPYY	ITCH	834:837	Mutation altering degron motif	0.7582
p.P782H	TCGA-BH-A0DI	BRCA	TCGA	PPAY	ITCH	781:784	Mutation altering degron motif	0.7694
p.S751N	TCGA-BR-4184	STAD	TCGA	ANTST	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.1389
p.T75I	TCGA-BT-A0YX	BLCA	TCGA	LQPHAE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1111
p.P736H	TCGA-CG-4442	STAD	TCGA	ANTST	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.2222
p.P794T	TCGA-D3-A2J6	SKCM	TCGA	NPAPYTPPP	CBL_PTK	793:801	Mutation altering degron motif	0.5919
p.P777L	TCGA-D3-A8GM	SKCM	TCGA	PPAY	ITCH	781:784	Mutation rewiring degron network	0.2222
p.V747I	TCGA-D5-6928	COAD	TCGA	ANTST	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.25
p.P799L	TCGA-EE-A2M5	SKCM	TCGA	NPAPYTPPP	CBL_PTK	793:801	Mutation altering degron motif	0.6471
p.G24D	TCGA-G4-6309	COAD	TCGA	LQRRGLDTR	SCF_FBXL2	15:23	Mutation rewiring degron network	0.3056
p.G24D	DO7810	COAD	ICGC	LQRRGLDTR	SCF_FBXL2	15:23	Mutation rewiring degron network	0.3056
p.A805S	TCGA-NC-A5HM	LUSC	TCGA	NPAPYTPPP	CBL_PTK	793:801	Mutation rewiring degron network	0.2222
p.K731N	TCGA-ZF-AA51	BLCA	TCGA	ANTST	DEG_SPOP_SBC_1	740:744	Mutation substituting flanking lysine	0.1944
p.N8K	DO5936	BRCA	ICGC	LQRRGLDTR	SCF_FBXL2	15:23	Mutation rewiring degron network	0.1389
p.P721S	DO223732	CESC	ICGC	PPSY	ITCH	714:717	Mutation rewiring degron network	0.2222
p.E25K	DO9844	COAD	ICGC	LQRRGLDTR	SCF_FBXL2	15:23	Mutation rewiring degron network	0.2778
p.E25K	DO43306	UCEC	ICGC	LQRRGLDTR	SCF_FBXL2	15:23	Mutation rewiring degron network	0.2778
p.F10L	DO8264	COAD	ICGC	LQRRGLDTR	SCF_FBXL2	15:23	Mutation rewiring degron network	0.1944
p.A705P	DO222874	COCA	ICGC	PPSY	ITCH	714:717	Mutation rewiring degron network	0.0833
p.D12Y	DO228924	LICA	ICGC	LQRRGLDTR	SCF_FBXL2	15:23	Mutation rewiring degron network	0.25
p.R79P	DO228899	LICA	ICGC	LQPHAE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.2222
p.F84C	DO50931	LICA	ICGC	LQPHAE	LIG_APCC_ABBA_1	83:88	Mutation altering degron motif	0.7108
p.D89Y	DO50931	LICA	ICGC	LQPHAE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.3056
p.A715S	DO219195	LUSC	ICGC	PPSY	ITCH	714:717	Mutation altering degron motif	0.7588
p.P719S	DO220878	MELA	ICGC	PPSY	ITCH	714:717	Mutation rewiring degron network	0.2778
p.P74S	DO35196	PACA	ICGC	LQPHAE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.0833
p.G748R	DO228142	PBCA	ICGC	ANTST	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.2222
p.P713L	DO228017	SKCA	ICGC	PPSY	ITCH	714:717	Mutation rewiring degron network	0.3056
p.P709L	DO37425	SKCM	ICGC	PPSY	ITCH	714:717	Mutation rewiring degron network	0.1944
p.P704T	DO37901	SKCM	ICGC	PPSY	ITCH	714:717	Mutation rewiring degron network	0.0556
p.E88D	DO38715	STAD	ICGC	LQPHAE	LIG_APCC_ABBA_1	83:88	Mutation altering degron motif	0.5647
p.Q96R	DO47867	STAD	ICGC	LQPHAE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1111
p.P95H	DO40843	UCEC	ICGC	LQPHAE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1389
p.T13A	DO41584	UCEC	ICGC	LQRRGLDTR	SCF_FBXL2	15:23	Mutation rewiring degron network	0.2778
p.P744L	DO41871	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	740:744	Mutation altering degron motif	0.7582
p.Y11D	DO41133	UCEC	ICGC	LQRRGLDTR	SCF_FBXL2	15:23	Mutation rewiring degron network	0.2222
p.Q16L	SIDM01280	Esophageal Carcinoma	GDSC	LQRRGLDTR	SCF_FBXL2	15:23	Mutation altering degron motif	0.7765
p.P706T	SIDM00629	Breast Carcinoma	GDSC	PPSY	ITCH	714:717	Mutation rewiring degron network	0.1111
p.P706T	ACH-000573	Breast Cancer	CCLE	PPSY	ITCH	714:717	Mutation rewiring degron network	0.1111
p.A805T	SIDM00216	Colorectal Carcinoma	GDSC	NPAPYTPPP	CBL_PTK	793:801	Mutation rewiring degron network	0.2222
p.A805T	ACH-000989	Colon/Colorectal Cancer	CCLE	NPAPYTPPP	CBL_PTK	793:801	Mutation rewiring degron network	0.2222
p.A805T	SNU-175	large intestine	COSMIC	NPAPYTPPP	CBL_PTK	793:801	Mutation rewiring degron network	0.2222
p.A740T	SIDM00108	Melanoma	GDSC	ANTST	DEG_SPOP_SBC_1	740:744	Mutation altering degron motif	0.7139
p.A740T	ACH-000579	Skin Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	740:744	Mutation altering degron motif	0.7139
p.A740T	UACC-257	skin	COSMIC	ANTST	DEG_SPOP_SBC_1	740:744	Mutation altering degron motif	0.7139
p.A87P	SIDM00845	Burkitt's Lymphoma	GDSC	LQPHAE	LIG_APCC_ABBA_1	83:88	Mutation altering degron motif	0.6392
p.N824S	SIDM00845	Burkitt's Lymphoma	GDSC	PPYY	ITCH	834:837	Mutation rewiring degron network	0.0556
p.G831S	SIDM00845	Burkitt's Lymphoma	GDSC	PPYY	ITCH	834:837	Mutation rewiring degron network	0.25
p.G791S	SIDM01078	Small Cell Lung Carcinoma	GDSC	NPAPYTPPP	CBL_PTK	793:801	Mutation rewiring degron network	0.2778
p.G791S	SIDM01078	Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	781:784	Mutation rewiring degron network	0.1389
p.G791S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	NPAPYTPPP	CBL_PTK	793:801	Mutation rewiring degron network	0.2778
p.G791S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	781:784	Mutation rewiring degron network	0.1389
p.Q825K	SIDM00670	Pancreatic Carcinoma	GDSC	PPYY	ITCH	834:837	Mutation rewiring degron network	0.0833
p.Q825K	HPAC	pancreas	COSMIC	PPYY	ITCH	834:837	Mutation rewiring degron network	0.0833
p.Y789H	SIDM00537	Colorectal Carcinoma	GDSC	NPAPYTPPP	CBL_PTK	793:801	Mutation rewiring degron network	0.2222
p.Y789H	SIDM00537	Colorectal Carcinoma	GDSC	PPAY	ITCH	781:784	Mutation rewiring degron network	0.1944
p.Y789H	ACH-000982	Colon/Colorectal Cancer	CCLE	NPAPYTPPP	CBL_PTK	793:801	Mutation rewiring degron network	0.2222
p.Y789H	ACH-000982	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	781:784	Mutation rewiring degron network	0.1944
p.Y789H	ACH-001345	Colon/Colorectal Cancer	CCLE	NPAPYTPPP	CBL_PTK	793:801	Mutation rewiring degron network	0.2222
p.Y789H	ACH-001345	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	781:784	Mutation rewiring degron network	0.1944
p.Y789H	GP5d	large intestine	COSMIC	NPAPYTPPP	CBL_PTK	793:801	Mutation rewiring degron network	0.2222
p.Y789H	GP5d	large intestine	COSMIC	PPAY	ITCH	781:784	Mutation rewiring degron network	0.1944
p.P800L	SIDM00217	Colorectal Carcinoma	GDSC	NPAPYTPPP	CBL_PTK	793:801	Mutation altering degron motif	0.6471
p.P800L	ACH-000999	Colon/Colorectal Cancer	CCLE	NPAPYTPPP	CBL_PTK	793:801	Mutation altering degron motif	0.6471
p.P800L	SNU-1040	large intestine	COSMIC	NPAPYTPPP	CBL_PTK	793:801	Mutation altering degron motif	0.6471
p.Y836H	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPYY	ITCH	834:837	Mutation altering degron motif	0.6118
p.Y836H	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PPYY	ITCH	834:837	Mutation altering degron motif	0.6118
p.R12S	ACH-001819	Breast Cancer	CCLE	LQRRGLDTR	SCF_FBXL2	15:23	Mutation rewiring degron network	0.25
p.G847R	ACH-002065	Sarcoma	CCLE	PPYY	ITCH	834:837	Mutation rewiring degron network	0.0556
p.E73K	ACH-002166	Skin Cancer	CCLE	LQPHAE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.0556
p.E73K	MZ7-mel	skin	COSMIC	LQPHAE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.0556
p.Y732H	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.1111
p.A705T	SNU-175	large intestine	COSMIC	PPSY	ITCH	714:717	Mutation rewiring degron network	0.0833
p.Q735K	HPAC	pancreas	COSMIC	ANTST	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.1944
p.P711L	SNU-1040	large intestine	COSMIC	PPSY	ITCH	714:717	Mutation rewiring degron network	0.25
p.T749A	C-33-A	cervix	COSMIC	ANTST	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.1944
p.L98P	GP5d	large intestine	COSMIC	LQPHAE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.0556
p.Q773K	HPAC	pancreas	COSMIC	PPAY	ITCH	781:784	Mutation rewiring degron network	0.1111
p.Q9R	EN	endometrium	COSMIC	LQRRGLDTR	SCF_FBXL2	15:23	Mutation rewiring degron network	0.1667
p.Q736K	HPAC	pancreas	COSMIC	ANTST	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.2222
p.T797A	C-33-A	cervix	COSMIC	NPAPYTPPP	CBL_PTK	793:801	Mutation altering degron motif	0.7139
p.Y746H	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.2778
p.P710L	SNU-1040	large intestine	COSMIC	PPSY	ITCH	714:717	Mutation rewiring degron network	0.2222
p.Q725K	HPAC	pancreas	COSMIC	PPSY	ITCH	714:717	Mutation rewiring degron network	0.1111
p.Q20R	EN	endometrium	COSMIC	LQRRGLDTR	SCF_FBXL2	15:23	Mutation altering degron motif	0.7329
p.Y736H	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.2222
p.T745A	C-33-A	cervix	COSMIC	ANTST	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.3056
p.Y747H	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	740:744	Mutation rewiring degron network	0.25
p.Q721K	HPAC	pancreas	COSMIC	PPSY	ITCH	714:717	Mutation rewiring degron network	0.2222
p.Y784H	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	781:784	Mutation altering degron motif	0.7229
p.A716T	SNU-175	large intestine	COSMIC	PPSY	ITCH	714:717	Mutation altering degron motif	0.7139
p.A715T	SNU-175	large intestine	COSMIC	PPSY	ITCH	714:717	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HNRNPUL1

UniProt ID: Q9BUJ2

Entrez ID: 11100

Protein name: Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HNRNPUL1 in