DegronMD

Uniprot ID: Q9BUJ2

Source protein: Heterogeneous nuclear ribonucleoprotein U-like protein 1

Source gene: HNRNPUL1

Class: SCF_FBXL2

Location: 15:23

E3 ligase: FBXL2

DEGRON score: 0.5179

ASA_SCORE: 88.4111

COIL: 0.5641

CONS_SCORE: 0.4136

DSS_SCORE: 0.3374

HELIX: 0.4297

FCONS_SCORE: 1.0098

RIG_SCORE: 0.74

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G24D	TCGA-G4-6309	COAD	TCGA	LQRRGLDTR	SCF_FBXL2	0.3056
p.G24D	DO7810	COAD	ICGC	LQRRGLDTR	SCF_FBXL2	0.3056
p.N8K	DO5936	BRCA	ICGC	LQRRGLDTR	SCF_FBXL2	0.1389
p.E25K	DO9844	COAD	ICGC	LQRRGLDTR	SCF_FBXL2	0.2778
p.E25K	DO43306	UCEC	ICGC	LQRRGLDTR	SCF_FBXL2	0.2778
p.F10L	DO8264	COAD	ICGC	LQRRGLDTR	SCF_FBXL2	0.1944
p.D12Y	DO228924	LICA	ICGC	LQRRGLDTR	SCF_FBXL2	0.25
p.T13A	DO41584	UCEC	ICGC	LQRRGLDTR	SCF_FBXL2	0.2778
p.Y11D	DO41133	UCEC	ICGC	LQRRGLDTR	SCF_FBXL2	0.2222
p.Q16L	SIDM01280	Esophageal Carcinoma	GDSC	LQRRGLDTR	SCF_FBXL2	0.7765
p.R12S	ACH-001819	Breast Cancer	CCLE	LQRRGLDTR	SCF_FBXL2	0.25
p.Q9R	EN	endometrium	COSMIC	LQRRGLDTR	SCF_FBXL2	0.1667
p.Q20R	EN	endometrium	COSMIC	LQRRGLDTR	SCF_FBXL2	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	SCF_FBXL2	15:23	LQRRGLDTR	FBXL2	0.5179	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons