DegronMD

Uniprot ID: Q9BUJ2

Source protein: Heterogeneous nuclear ribonucleoprotein U-like protein 1

Source gene: HNRNPUL1

Class: DEG_SPOP_SBC_1

Location: 740:744

E3 ligase: SPOP

DEGRON score: 0.9875

ASA_SCORE: 57.48

COIL: 0.9238

CONS_SCORE: 0.3369

DSS_SCORE: 0.6307

HELIX: 0.0486

FCONS_SCORE: 0.9841

RIG_SCORE: 0.5612

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S751N	TCGA-BR-4184	STAD	TCGA	ANTST	DEG_SPOP_SBC_1	0.1389
p.P736H	TCGA-CG-4442	STAD	TCGA	ANTST	DEG_SPOP_SBC_1	0.2222
p.V747I	TCGA-D5-6928	COAD	TCGA	ANTST	DEG_SPOP_SBC_1	0.25
p.K731N	TCGA-ZF-AA51	BLCA	TCGA	ANTST	DEG_SPOP_SBC_1	0.1944
p.G748R	DO228142	PBCA	ICGC	ANTST	DEG_SPOP_SBC_1	0.2222
p.P744L	DO41871	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	0.7582
p.A740T	SIDM00108	Melanoma	GDSC	ANTST	DEG_SPOP_SBC_1	0.7139
p.A740T	ACH-000579	Skin Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	0.7139
p.A740T	UACC-257	skin	COSMIC	ANTST	DEG_SPOP_SBC_1	0.7139
p.Y732H	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	0.1111
p.Q735K	HPAC	pancreas	COSMIC	ANTST	DEG_SPOP_SBC_1	0.1944
p.T749A	C-33-A	cervix	COSMIC	ANTST	DEG_SPOP_SBC_1	0.1944
p.Q736K	HPAC	pancreas	COSMIC	ANTST	DEG_SPOP_SBC_1	0.2222
p.Y746H	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	0.2778
p.Y736H	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	0.2222
p.T745A	C-33-A	cervix	COSMIC	ANTST	DEG_SPOP_SBC_1	0.3056
p.Y747H	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11940	Polyadenylate-binding protein 1	DEG_SPOP_SBC_1	483:487	ANTST	SPOP	0.9929	More...
Q5XPI4	E3 ubiquitin-protein ligase RNF123	DEG_SPOP_SBC_1	1305:1309	ANTST	SPOP	0.618	More...
Q6ZRI0	Otogelin	DEG_SPOP_SBC_1	2046:2050	ANTST	SPOP	0.621	More...
Q86WI1	Fibrocystin-L	DEG_SPOP_SBC_1	2964:2968	ANTST	SPOP	0.8314	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	DEG_SPOP_SBC_1	740:744	ANTST	SPOP	0.9875	More...
Q9H361	Polyadenylate-binding protein 3	DEG_SPOP_SBC_1	477:481	ANTST	SPOP	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons