DegronMD

Uniprot ID: Q6ZRI0

Source protein: Otogelin

Source gene: OTOG

Class: DEG_SPOP_SBC_1

Location: 2046:2050

E3 ligase: SPOP

DEGRON score: 0.621

ASA_SCORE: 78.46

COIL: 0.8536

CONS_SCORE: 0.4257

DSS_SCORE: 0.3086

HELIX: 0.0916

FCONS_SCORE: 0.8782

RIG_SCORE: 0.7599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2037V	SIDM01278	Colorectal Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	0.0833
p.A2037V	SIDM00211	B-Lymphoblastic Leukemia	GDSC	ANTST	DEG_SPOP_SBC_1	0.0833
p.A2037V	SIDM01063	Acute Myeloid Leukemia	GDSC	ANTST	DEG_SPOP_SBC_1	0.0833
p.A2037V	SIDM01140	Ovarian Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	0.0833
p.A2037V	SIDM00458	Acute Myeloid Leukemia	GDSC	ANTST	DEG_SPOP_SBC_1	0.0833
p.R2060L	A172	central_nervous_system	COSMIC	ANTST	DEG_SPOP_SBC_1	0.0556
p.R2060L	JVM-2	haematopoietic_and_lymphoid_tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	0.0556
p.R2060L	D-245MG	central_nervous_system	COSMIC	ANTST	DEG_SPOP_SBC_1	0.0556
p.R2060H	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	0.0556
p.R2060H	MZ2-MEL	skin	COSMIC	ANTST	DEG_SPOP_SBC_1	0.0556
p.R2060H	OAW-28	ovary	COSMIC	ANTST	DEG_SPOP_SBC_1	0.0556
p.L2058M	SNU-C1	large_intestine	COSMIC	ANTST	DEG_SPOP_SBC_1	0.1111
p.R2050H	SNU-1040	large_intestine	COSMIC	ANTST	DEG_SPOP_SBC_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11940	Polyadenylate-binding protein 1	DEG_SPOP_SBC_1	483:487	ANTST	SPOP	0.9929	More...
Q5XPI4	E3 ubiquitin-protein ligase RNF123	DEG_SPOP_SBC_1	1305:1309	ANTST	SPOP	0.618	More...
Q6ZRI0	Otogelin	DEG_SPOP_SBC_1	2046:2050	ANTST	SPOP	0.621	More...
Q86WI1	Fibrocystin-L	DEG_SPOP_SBC_1	2964:2968	ANTST	SPOP	0.8314	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	DEG_SPOP_SBC_1	740:744	ANTST	SPOP	0.9875	More...
Q9H361	Polyadenylate-binding protein 3	DEG_SPOP_SBC_1	477:481	ANTST	SPOP	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons