DegronMD

Uniprot ID: Q9H361

Source protein: Polyadenylate-binding protein 3

Source gene: PABPC3

Class: DEG_SPOP_SBC_1

Location: 477:481

E3 ligase: SPOP

DEGRON score: 0.9952

ASA_SCORE: 81.98

COIL: 0.927

CONS_SCORE: 0.26

DSS_SCORE: 0.6179

HELIX: 0.0504

FCONS_SCORE: 0.9036

RIG_SCORE: 0.6858

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A477V	TCGA-AA-A010	COAD	TCGA	ANTST	DEG_SPOP_SBC_1	0.5825
p.Q482H	TCGA-AN-A046	BRCA	TCGA	ANTST	DEG_SPOP_SBC_1	0.3056
p.Q482H	DO1285	BRCA	ICGC	ANTST	DEG_SPOP_SBC_1	0.3056
p.R475H	TCGA-AP-A0LM	UCEC	TCGA	ANTST	DEG_SPOP_SBC_1	0.2778
p.R475H	DO43306	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	0.2778
p.T473M	TCGA-GV-A3JZ	BLCA	TCGA	ANTST	DEG_SPOP_SBC_1	0.2222
p.T473M	TCGA-VQ-A8P5	STAD	TCGA	ANTST	DEG_SPOP_SBC_1	0.2222
p.T473M	DO773	BLCA	ICGC	ANTST	DEG_SPOP_SBC_1	0.2222
p.T473M	DO51763	STAD	ICGC	ANTST	DEG_SPOP_SBC_1	0.2222
p.T473M	SIDM00943	Pancreatic Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	0.2222
p.T473M	ACH-000107	Pancreatic Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	0.2222
p.T473M	Capan-2	pancreas	COSMIC	ANTST	DEG_SPOP_SBC_1	0.2222
p.V484M	DO48449	BLCA	ICGC	ANTST	DEG_SPOP_SBC_1	0.25
p.V484M	DO228926	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.25
p.V484M	DO228967	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.25
p.V484M	DO228972	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.25
p.V484M	DO229015	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.25
p.V484M	DO229034	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.25
p.V484M	DO229041	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.25
p.V484M	DO229046	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.25
p.R487C	DO48449	BLCA	ICGC	ANTST	DEG_SPOP_SBC_1	0.1667
p.A489T	DO230347	COCA	ICGC	ANTST	DEG_SPOP_SBC_1	0.1111
p.V470I	DO233797	GACA	ICGC	ANTST	DEG_SPOP_SBC_1	0.1389
p.R475C	DO228965	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.2778
p.R475C	DO228972	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.2778
p.R475C	DO229034	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.2778
p.R475C	DO229047	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.2778
p.R475C	DO229046	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.2778
p.R475C	DO229055	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.2778
p.R469Q	DO229047	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.1111
p.R469Q	DO229053	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.1111
p.R469Q	DO229062	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.1111
p.T479A	SIDM00333	Endometrial Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	0.7139
p.T479A	ACH-000988	Endometrial/Uterine Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	0.7139
p.T479A	MFE-319	endometrium	COSMIC	ANTST	DEG_SPOP_SBC_1	0.7139
p.S480L	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	0.8778
p.S480L	ACH-000852	Lung Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	0.8778
p.S480L	NCI-H1435	lung	COSMIC	ANTST	DEG_SPOP_SBC_1	0.8778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11940	Polyadenylate-binding protein 1	DEG_SPOP_SBC_1	483:487	ANTST	SPOP	0.9929	More...
Q5XPI4	E3 ubiquitin-protein ligase RNF123	DEG_SPOP_SBC_1	1305:1309	ANTST	SPOP	0.618	More...
Q6ZRI0	Otogelin	DEG_SPOP_SBC_1	2046:2050	ANTST	SPOP	0.621	More...
Q86WI1	Fibrocystin-L	DEG_SPOP_SBC_1	2964:2968	ANTST	SPOP	0.8314	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	DEG_SPOP_SBC_1	740:744	ANTST	SPOP	0.9875	More...
Q9H361	Polyadenylate-binding protein 3	DEG_SPOP_SBC_1	477:481	ANTST	SPOP	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ANTST

Degron related mutations and impact score

Drug responses associated with PABPC3 mutations

All proteins holding degron of ANTST