DegronMD - P11940(PABPC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M477I	TCGA-17-Z020	LUAD	TCGA	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1667
p.A496T	TCGA-A6-6781	COAD	TCGA	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.0833
p.V476D	TCGA-CJ-4907	KIRC	TCGA	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1389
p.V485L	DO222729	COCA	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.6765
p.V485L	DO229045	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.6765
p.V485L	DO52376	LUSC	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.6765
p.V485L	DO229229	THCA	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.6765
p.V476F	DO52118	HNSC	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1389
p.V473I	DO50978	LAML	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.0556
p.V473I	DO229240	THCA	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.0556
p.R474C	DO50978	LAML	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.0833
p.R474C	DO229084	THCA	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.0833
p.R486G	DO228863	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.7568
p.N493S	DO22866	LIHC	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1667
p.N487S	DO27357	LUSC	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.7069
p.P477A	DO50726	ORCA	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1667
p.R486C	DO37406	SKCM	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.8301
p.R486C	DO43041	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.8301
p.R486C	DO41758	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.8301
p.R486C	DO41903	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.8301
p.Q489R	DO42097	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.2778
p.M490V	SIDM00177	Melanoma	GDSC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.25
p.M490V	ACH-002338	Skin Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.25
p.M490V	ACH-002510	Skin Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.25
p.M482I	no-10	central nervous system	COSMIC	ANTST	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.3056

Kaplan plot for PABPC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PABPC1

UniProt ID: P11940

Entrez ID: 26986

Protein name: Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PABPC1 in