DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ANTST
Uniprot ID:
P11940
Source protein:
Polyadenylate-binding protein 1
Source gene:
PABPC1
Class:
DEG_SPOP_SBC_1
Location:
483:487
E3 ligase:
SPOP
DEGRON score:
0.9929
ASA_SCORE:
75.72
COIL:
0.9218
CONS_SCORE:
0.2787
DSS_SCORE:
0.6586
HELIX:
0.0466
FCONS_SCORE:
0.969
RIG_SCORE:
0.679
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R486C
DO37406
SKCM
ICGC
ANTST
DEG_SPOP_SBC_1
0.8301
p.R486C
DO43041
UCEC
ICGC
ANTST
DEG_SPOP_SBC_1
0.8301
p.R486C
DO41758
UCEC
ICGC
ANTST
DEG_SPOP_SBC_1
0.8301
p.R486C
DO41903
UCEC
ICGC
ANTST
DEG_SPOP_SBC_1
0.8301
p.R486G
DO228863
LICA
ICGC
ANTST
DEG_SPOP_SBC_1
0.7568
p.N487S
DO27357
LUSC
ICGC
ANTST
DEG_SPOP_SBC_1
0.7069
p.V485L
DO222729
COCA
ICGC
ANTST
DEG_SPOP_SBC_1
0.6765
p.V485L
DO229045
LICA
ICGC
ANTST
DEG_SPOP_SBC_1
0.6765
p.V485L
DO52376
LUSC
ICGC
ANTST
DEG_SPOP_SBC_1
0.6765
p.V485L
DO229229
THCA
ICGC
ANTST
DEG_SPOP_SBC_1
0.6765
p.M482I
no-10
central_nervous_system
COSMIC
ANTST
DEG_SPOP_SBC_1
0.3056
p.Q489R
DO42097
UCEC
ICGC
ANTST
DEG_SPOP_SBC_1
0.2778
p.M490V
SIDM00177
Melanoma
GDSC
ANTST
DEG_SPOP_SBC_1
0.25
p.M490V
ACH-002338
Skin Cancer
CCLE
ANTST
DEG_SPOP_SBC_1
0.25
p.M490V
ACH-002510
Skin Cancer
CCLE
ANTST
DEG_SPOP_SBC_1
0.25
p.M477I
TCGA-17-Z020
LUAD
TCGA
ANTST
DEG_SPOP_SBC_1
0.1667
p.N493S
DO22866
LIHC
ICGC
ANTST
DEG_SPOP_SBC_1
0.1667
p.P477A
DO50726
ORCA
ICGC
ANTST
DEG_SPOP_SBC_1
0.1667
p.V476D
TCGA-CJ-4907
KIRC
TCGA
ANTST
DEG_SPOP_SBC_1
0.1389
p.V476F
DO52118
HNSC
ICGC
ANTST
DEG_SPOP_SBC_1
0.1389
p.A496T
TCGA-A6-6781
COAD
TCGA
ANTST
DEG_SPOP_SBC_1
0.0833
p.R474C
DO50978
LAML
ICGC
ANTST
DEG_SPOP_SBC_1
0.0833
p.R474C
DO229084
THCA
ICGC
ANTST
DEG_SPOP_SBC_1
0.0833
p.V473I
DO50978
LAML
ICGC
ANTST
DEG_SPOP_SBC_1
0.0556
p.V473I
DO229240
THCA
ICGC
ANTST
DEG_SPOP_SBC_1
0.0556
Showing 1 to 25 of 25 entries
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Drug responses associated with PABPC1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of ANTST
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5XPI4
E3 ubiquitin-protein ligase RNF123
DEG_SPOP_SBC_1
1305:1309
ANTST
SPOP
0.618
More...
Q86WI1
Fibrocystin-L
DEG_SPOP_SBC_1
2964:2968
ANTST
SPOP
0.8314
More...
Q9BUJ2
Heterogeneous nuclear ribonucleoprotein U-like protein 1
DEG_SPOP_SBC_1
740:744
ANTST
SPOP
0.9875
More...
Q6ZRI0
Otogelin
DEG_SPOP_SBC_1
2046:2050
ANTST
SPOP
0.621
More...
P11940
Polyadenylate-binding protein 1
DEG_SPOP_SBC_1
483:487
ANTST
SPOP
0.9929
More...
Q9H361
Polyadenylate-binding protein 3
DEG_SPOP_SBC_1
477:481
ANTST
SPOP
0.9952
More...
Showing 1 to 6 of 6 entries
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