DegronMD

Uniprot ID: P11940

Source protein: Polyadenylate-binding protein 1

Source gene: PABPC1

Class: DEG_SPOP_SBC_1

Location: 483:487

E3 ligase: SPOP

DEGRON score: 0.9929

ASA_SCORE: 75.72

COIL: 0.9218

CONS_SCORE: 0.2787

DSS_SCORE: 0.6586

HELIX: 0.0466

FCONS_SCORE: 0.969

RIG_SCORE: 0.679

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M477I	TCGA-17-Z020	LUAD	TCGA	ANTST	DEG_SPOP_SBC_1	0.1667
p.A496T	TCGA-A6-6781	COAD	TCGA	ANTST	DEG_SPOP_SBC_1	0.0833
p.V476D	TCGA-CJ-4907	KIRC	TCGA	ANTST	DEG_SPOP_SBC_1	0.1389
p.V485L	DO222729	COCA	ICGC	ANTST	DEG_SPOP_SBC_1	0.6765
p.V485L	DO229045	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.6765
p.V485L	DO52376	LUSC	ICGC	ANTST	DEG_SPOP_SBC_1	0.6765
p.V485L	DO229229	THCA	ICGC	ANTST	DEG_SPOP_SBC_1	0.6765
p.V476F	DO52118	HNSC	ICGC	ANTST	DEG_SPOP_SBC_1	0.1389
p.V473I	DO50978	LAML	ICGC	ANTST	DEG_SPOP_SBC_1	0.0556
p.V473I	DO229240	THCA	ICGC	ANTST	DEG_SPOP_SBC_1	0.0556
p.R474C	DO50978	LAML	ICGC	ANTST	DEG_SPOP_SBC_1	0.0833
p.R474C	DO229084	THCA	ICGC	ANTST	DEG_SPOP_SBC_1	0.0833
p.R486G	DO228863	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	0.7568
p.N493S	DO22866	LIHC	ICGC	ANTST	DEG_SPOP_SBC_1	0.1667
p.N487S	DO27357	LUSC	ICGC	ANTST	DEG_SPOP_SBC_1	0.7069
p.P477A	DO50726	ORCA	ICGC	ANTST	DEG_SPOP_SBC_1	0.1667
p.R486C	DO37406	SKCM	ICGC	ANTST	DEG_SPOP_SBC_1	0.8301
p.R486C	DO43041	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	0.8301
p.R486C	DO41758	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	0.8301
p.R486C	DO41903	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	0.8301
p.Q489R	DO42097	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	0.2778
p.M490V	SIDM00177	Melanoma	GDSC	ANTST	DEG_SPOP_SBC_1	0.25
p.M490V	ACH-002338	Skin Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	0.25
p.M490V	ACH-002510	Skin Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	0.25
p.M482I	no-10	central_nervous_system	COSMIC	ANTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11940	Polyadenylate-binding protein 1	DEG_SPOP_SBC_1	483:487	ANTST	SPOP	0.9929	More...
Q5XPI4	E3 ubiquitin-protein ligase RNF123	DEG_SPOP_SBC_1	1305:1309	ANTST	SPOP	0.618	More...
Q6ZRI0	Otogelin	DEG_SPOP_SBC_1	2046:2050	ANTST	SPOP	0.621	More...
Q86WI1	Fibrocystin-L	DEG_SPOP_SBC_1	2964:2968	ANTST	SPOP	0.8314	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	DEG_SPOP_SBC_1	740:744	ANTST	SPOP	0.9875	More...
Q9H361	Polyadenylate-binding protein 3	DEG_SPOP_SBC_1	477:481	ANTST	SPOP	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons