DegronMD - Q86WI1(PKHD1L1)

GO - Biological processes (BP): immune response [GO:0006955]; sensory perception of sound [GO:0007605]

GO - Molecular function (MF): signaling receptor activity [GO:0038023]

GO - Cellular component (CC): cytosol [GO:0005829]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; stereocilium coat [GO:0120234]; stereocilium tip [GO:0032426]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R3719S	TCGA-BS-A0UF	UCEC	TCGA	DYR	CBL_MET	3717:3719	Mutation altering degron motif	0.7427
p.R3719S	DO41488	UCEC	ICGC	DYR	CBL_MET	3717:3719	Mutation altering degron motif	0.7427
p.S2967R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation altering degron motif	0.7427
p.S2967R	ACH-000981	Leukemia	CCLE	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation altering degron motif	0.7427
p.S2967R	DND-41	haematopoietic and lymphoid tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation altering degron motif	0.7427
p.S2967I	TCGA-CN-6010	HNSC	TCGA	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation altering degron motif	0.7341
p.S2967I	DO14766	HNSC	ICGC	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation altering degron motif	0.7341
p.T2968N	DO229248	THCA	ICGC	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation altering degron motif	0.7055
p.W641C	TCGA-GN-A262	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation altering degron motif	0.7
p.W641C	DO37515	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation altering degron motif	0.7
p.T638S	TCGA-FR-A8YC	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation altering degron motif	0.6005
p.T638S	DO50301	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation altering degron motif	0.6005
p.K3722E	TCGA-EE-A182	SKCM	TCGA	DYR	CBL_MET	3717:3719	Mutation substituting flanking lysine	0.3611
p.K3722E	DO37814	SKCM	ICGC	DYR	CBL_MET	3717:3719	Mutation substituting flanking lysine	0.3611
p.A645T	TCGA-AX-A1CE	UCEC	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.3056
p.A645T	DO42280	UCEC	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.3056
p.A645T	SIDM00937	Oral Cavity Carcinoma	GDSC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.3056
p.A645T	CAL-27	upper aerodigestive tract	COSMIC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.3056
p.P3721T	TCGA-AX-A2HC	UCEC	TCGA	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.2778
p.P3721T	DO41572	UCEC	ICGC	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 51 entries

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Kaplan plot for PKHD1L1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKHD1L1

UniProt ID: Q86WI1

Entrez ID: 93035

Protein name: Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKHD1L1 in