DegronMD - Q86WI1(PKHD1L1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L634F	TCGA-22-5481	LUSC	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.25
p.L634F	DO27160	LUSC	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.25
p.P648T	TCGA-60-2698	LUSC	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.2222
p.P648T	DO26469	LUSC	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.2222
p.K629I	TCGA-98-8023	LUSC	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation substituting flanking lysine	0.2222
p.K629I	DO26668	LUSC	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation substituting flanking lysine	0.2222
p.G3709R	TCGA-AG-A002	READ	TCGA	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.1111
p.G3709R	SIDM00107	Melanoma	GDSC	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.1111
p.G3709R	SIDM01629	Melanoma	GDSC	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.1111
p.L3725F	TCGA-AP-A0LM	UCEC	TCGA	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.1667
p.L3725F	DO43306	UCEC	ICGC	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.1667
p.A645T	TCGA-AX-A1CE	UCEC	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.3056
p.A645T	DO42280	UCEC	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.3056
p.A645T	SIDM00937	Oral Cavity Carcinoma	GDSC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.3056
p.A645T	CAL-27	upper aerodigestive tract	COSMIC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.3056
p.P3721T	TCGA-AX-A2HC	UCEC	TCGA	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.2778
p.P3721T	DO41572	UCEC	ICGC	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.2778
p.R3719S	TCGA-BS-A0UF	UCEC	TCGA	DYR	CBL_MET	3717:3719	Mutation altering degron motif	0.7427
p.R3719S	DO41488	UCEC	ICGC	DYR	CBL_MET	3717:3719	Mutation altering degron motif	0.7427
p.S2967I	TCGA-CN-6010	HNSC	TCGA	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation altering degron motif	0.7341
p.S2967I	DO14766	HNSC	ICGC	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation altering degron motif	0.7341
p.K3722E	TCGA-EE-A182	SKCM	TCGA	DYR	CBL_MET	3717:3719	Mutation substituting flanking lysine	0.3611
p.K3722E	DO37814	SKCM	ICGC	DYR	CBL_MET	3717:3719	Mutation substituting flanking lysine	0.3611
p.S646F	TCGA-EE-A29E	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.2778
p.S646F	DO37831	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.2778
p.T638S	TCGA-FR-A8YC	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation altering degron motif	0.6005
p.T638S	DO50301	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation altering degron motif	0.6005
p.G630E	TCGA-GF-A3OT	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.1389
p.G630E	TCGA-GN-A4U7	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.1389
p.G630E	TCGA-W3-AA1R	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.1389
p.G630E	DO47288	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.1389
p.G630E	DO51275	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.1389
p.G630E	DO51258	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation rewiring degron network	0.1389
p.W641C	TCGA-GN-A262	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation altering degron motif	0.7
p.W641C	DO37515	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation altering degron motif	0.7
p.R2976K	TCGA-IR-A3LK	CESC	TCGA	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation rewiring degron network	0.1111
p.R2976K	DO44299	CESC	ICGC	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation rewiring degron network	0.1111
p.R2976K	DO220877	MELA	ICGC	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation rewiring degron network	0.1111
p.K2956N	TCGA-MN-A4N4	LUAD	TCGA	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation substituting flanking lysine	0.2222
p.K2956N	DO26250	LUAD	ICGC	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation substituting flanking lysine	0.2222
p.D3708Y	TCGA-OR-A5J7	ACC	TCGA	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.0833
p.K631N	DO231243	LAML	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	637:644	Mutation substituting flanking lysine	0.2778
p.I3715T	DO51519	PACA	ICGC	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.2778
p.P3721S	DO229462	SKCA	ICGC	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.2778
p.T2968N	DO229248	THCA	ICGC	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation altering degron motif	0.7055
p.S2967R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation altering degron motif	0.7427
p.S2967R	ACH-000981	Leukemia	CCLE	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation altering degron motif	0.7427
p.S2967R	DND-41	haematopoietic and lymphoid tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	2964:2968	Mutation altering degron motif	0.7427
p.F3727Y	SIDM00845	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.1111
p.A3723V	SIDM00193	Colorectal Carcinoma	GDSC	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.2222
p.A3723V	SNU-81	large intestine	COSMIC	DYR	CBL_MET	3717:3719	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKHD1L1

UniProt ID: Q86WI1

Entrez ID: 93035

Protein name: Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKHD1L1 in