DegronMD

Uniprot ID: Q86WI1

Source protein: Fibrocystin-L

Source gene: PKHD1L1

Class: DEG_MDM2_SWIB_1

Location: 637:644

E3 ligase: MDM2

DEGRON score: 0.6484

ASA_SCORE: 35.675

COIL: 0.2765

CONS_SCORE: 0.4621

DSS_SCORE: 0.294

HELIX: 0.006

FCONS_SCORE: 1.27

RIG_SCORE: 0.864

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L634F	TCGA-22-5481	LUSC	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	0.25
p.L634F	DO27160	LUSC	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	0.25
p.P648T	TCGA-60-2698	LUSC	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	0.2222
p.P648T	DO26469	LUSC	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	0.2222
p.K629I	TCGA-98-8023	LUSC	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	0.2222
p.K629I	DO26668	LUSC	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	0.2222
p.A645T	TCGA-AX-A1CE	UCEC	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	0.3056
p.A645T	DO42280	UCEC	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	0.3056
p.A645T	SIDM00937	Oral Cavity Carcinoma	GDSC	FTLNWDGI	DEG_MDM2_SWIB_1	0.3056
p.A645T	CAL-27	upper_aerodigestive_tract	COSMIC	FTLNWDGI	DEG_MDM2_SWIB_1	0.3056
p.S646F	TCGA-EE-A29E	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	0.2778
p.S646F	DO37831	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	0.2778
p.T638S	TCGA-FR-A8YC	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	0.6005
p.T638S	DO50301	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	0.6005
p.G630E	TCGA-GF-A3OT	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	0.1389
p.G630E	TCGA-GN-A4U7	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	0.1389
p.G630E	TCGA-W3-AA1R	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	0.1389
p.G630E	DO47288	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	0.1389
p.G630E	DO51275	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	0.1389
p.G630E	DO51258	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	0.1389
p.W641C	TCGA-GN-A262	SKCM	TCGA	FTLNWDGI	DEG_MDM2_SWIB_1	0.7
p.W641C	DO37515	SKCM	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	0.7
p.K631N	DO231243	LAML	ICGC	FTLNWDGI	DEG_MDM2_SWIB_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WI1	Fibrocystin-L	DEG_MDM2_SWIB_1	637:644	FTLNWDGI	MDM2	0.6484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons