DegronMD

Uniprot ID: Q86WI1

Source protein: Fibrocystin-L

Source gene: PKHD1L1

Class: DEG_SPOP_SBC_1

Location: 2964:2968

E3 ligase: SPOP

DEGRON score: 0.8314

ASA_SCORE: 56.46

COIL: 0.802

CONS_SCORE: 0.3423

DSS_SCORE: 0.2227

HELIX: 0.0688

FCONS_SCORE: 0.8053

RIG_SCORE: 0.8101

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2967I	TCGA-CN-6010	HNSC	TCGA	ANTST	DEG_SPOP_SBC_1	0.7341
p.S2967I	DO14766	HNSC	ICGC	ANTST	DEG_SPOP_SBC_1	0.7341
p.R2976K	TCGA-IR-A3LK	CESC	TCGA	ANTST	DEG_SPOP_SBC_1	0.1111
p.R2976K	DO44299	CESC	ICGC	ANTST	DEG_SPOP_SBC_1	0.1111
p.R2976K	DO220877	MELA	ICGC	ANTST	DEG_SPOP_SBC_1	0.1111
p.K2956N	TCGA-MN-A4N4	LUAD	TCGA	ANTST	DEG_SPOP_SBC_1	0.2222
p.K2956N	DO26250	LUAD	ICGC	ANTST	DEG_SPOP_SBC_1	0.2222
p.T2968N	DO229248	THCA	ICGC	ANTST	DEG_SPOP_SBC_1	0.7055
p.S2967R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ANTST	DEG_SPOP_SBC_1	0.7427
p.S2967R	ACH-000981	Leukemia	CCLE	ANTST	DEG_SPOP_SBC_1	0.7427
p.S2967R	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11940	Polyadenylate-binding protein 1	DEG_SPOP_SBC_1	483:487	ANTST	SPOP	0.9929	More...
Q5XPI4	E3 ubiquitin-protein ligase RNF123	DEG_SPOP_SBC_1	1305:1309	ANTST	SPOP	0.618	More...
Q6ZRI0	Otogelin	DEG_SPOP_SBC_1	2046:2050	ANTST	SPOP	0.621	More...
Q86WI1	Fibrocystin-L	DEG_SPOP_SBC_1	2964:2968	ANTST	SPOP	0.8314	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	DEG_SPOP_SBC_1	740:744	ANTST	SPOP	0.9875	More...
Q9H361	Polyadenylate-binding protein 3	DEG_SPOP_SBC_1	477:481	ANTST	SPOP	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons