DegronMD - Q6ZRI0(OTOG)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1788P	TCGA-AZ-4315	COAD	TCGA	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.1667
p.S1788P	DO8842	COAD	ICGC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.1667
p.P1807S	TCGA-CK-5913	COAD	TCGA	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.1667
p.P1807S	DO8826	COAD	ICGC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.1667
p.Q1870K	TCGA-D5-5540	COAD	TCGA	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1389
p.Q1870K	DO8738	COAD	ICGC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1389
p.L1802I	TCGA-EO-A22R	UCEC	TCGA	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.3056
p.L1802I	DO42713	UCEC	ICGC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.3056
p.P1874H	TCGA-LL-A5YL	BRCA	TCGA	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.25
p.P1874H	DO44166	BRCA	ICGC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.25
p.D1792N	TCGA-Q1-A73O	CESC	TCGA	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.2778
p.D1792N	DO51612	CESC	ICGC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.2778
p.G1883V	TCGA-SS-A7HO	COAD	TCGA	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation altering degron motif	0.6421
p.G1883V	DO223705	COAD	ICGC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation altering degron motif	0.6421
p.A1790V	TCGA-VS-A8EL	CESC	TCGA	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.2222
p.A1790V	DO51624	CESC	ICGC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.2222
p.P1873S	DO222404	BTCA	ICGC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.2222
p.T1947M	DO229016	COCA	ICGC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation altering degron motif	0.7423
p.T1947M	DO234285	ESAD	ICGC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation altering degron motif	0.7423
p.T1947M	DO229353	LAML	ICGC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation altering degron motif	0.7423
p.T1947M	DO51043	LAML	ICGC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation altering degron motif	0.7423
p.T1947M	DO230527	LUSC	ICGC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation altering degron motif	0.7423
p.T1947M	DO230529	LUSC	ICGC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation altering degron motif	0.7423
p.T1947M	DO230536	LUSC	ICGC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation altering degron motif	0.7423
p.T1947M	DO230937	LUSC	ICGC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation altering degron motif	0.7423
p.T1947M	DO231075	LUSC	ICGC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation altering degron motif	0.7423
p.A1784T	DO218693	GACA	ICGC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.0556
p.R1806H	DO15791	HNSC	ICGC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.1944
p.M1800I	DO228879	LICA	ICGC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation altering degron motif	0.6507
p.D1792Y	DO229025	LICA	ICGC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.2778
p.P1488S	DO50970	LICA	ICGC	LPTPSDE	DEG_SCF_FBW7_2	1487:1493	Mutation altering degron motif	0.5641
p.Q1485K	DO25189	LUAD	ICGC	LPTPSDE	DEG_SCF_FBW7_2	1487:1493	Mutation rewiring degron network	0.2778
p.T1955M	DO228344	MALY	ICGC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation rewiring degron network	0.2222
p.T1955M	SIDM00846	Cervical Carcinoma	GDSC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation rewiring degron network	0.2222
p.P1483S	DO222516	MELA	ICGC	LPTPSDE	DEG_SCF_FBW7_2	1487:1493	Mutation rewiring degron network	0.2222
p.E1960D	DO231284	PACA	ICGC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation rewiring degron network	0.0833
p.L1890R	DO229199	THCA	ICGC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation altering degron motif	0.8428
p.N54K	DO229240	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.A1871V	SIDM02039	Colorectal Carcinoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.A2037V	SIDM01278	Colorectal Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.0833
p.A2037V	SIDM00211	B-Lymphoblastic Leukemia	GDSC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.0833
p.A2037V	SIDM01063	Acute Myeloid Leukemia	GDSC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.0833
p.A2037V	SIDM01140	Ovarian Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.0833
p.A2037V	SIDM00458	Acute Myeloid Leukemia	GDSC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.0833
p.A1939T	SIDM00572	Gastric Carcinoma	GDSC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation rewiring degron network	0.1389
p.A1939T	ACH-000911	Gastric Cancer	CCLE	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation rewiring degron network	0.1389
p.A1939T	NUGC-3	stomach	COSMIC	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation rewiring degron network	0.1389
p.T1896A	SIDM00057	Neuroblastoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.T1896A	SIDM00596	Endometrial Carcinoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.T1896A	SIDM00290	Gastric Carcinoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.T1896A	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.T1896A	SIDM00357	Small Cell Lung Carcinoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.T1896A	SIDM00543	Melanoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.T1896A	HGC-27	stomach	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.T1896A	ACN	autonomic ganglia	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.T1896A	RERF-LC-FM	lung	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.T1896A	GAK	skin	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.T1896A	TE-4	oesophagus	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.T1896A	HEC-1	endometrium	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.1667
p.G1891R	SIDM00140	Melanoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.3056
p.G1891R	ACH-000968	Skin Cancer	CCLE	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.3056
p.G1891R	COLO-792	skin	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation rewiring degron network	0.3056
p.P1482S	SIDM00909	Melanoma	GDSC	LPTPSDE	DEG_SCF_FBW7_2	1487:1493	Mutation rewiring degron network	0.1944
p.P1482S	ACH-000644	Skin Cancer	CCLE	LPTPSDE	DEG_SCF_FBW7_2	1487:1493	Mutation rewiring degron network	0.1944
p.P1941L	ACH-000210	Bone Cancer	CCLE	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation rewiring degron network	0.1944
p.P1941L	ACH-000865	Esophageal Cancer	CCLE	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation rewiring degron network	0.1944
p.P1941L	ACH-001523	Skin Cancer	CCLE	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation rewiring degron network	0.1944
p.P1941L	ACH-001623	Brain Cancer	CCLE	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation rewiring degron network	0.1944
p.P1941L	ACH-002042	Thyroid Cancer	CCLE	LTPATS	DEG_SCF_FBW7_1	1946:1951	Mutation rewiring degron network	0.1944
p.P1792Q	ACH-000791	Lung Cancer	CCLE	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.2778
p.A70V	ACH-000930	Breast Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1944
p.E1493K	ACH-000979	Prostate Cancer	CCLE	LPTPSDE	DEG_SCF_FBW7_2	1487:1493	Mutation altering degron motif	0.7022
p.T1485M	ACH-000982	Colon/Colorectal Cancer	CCLE	LPTPSDE	DEG_SCF_FBW7_2	1487:1493	Mutation rewiring degron network	0.2778
p.T1485M	ACH-001345	Colon/Colorectal Cancer	CCLE	LPTPSDE	DEG_SCF_FBW7_2	1487:1493	Mutation rewiring degron network	0.2778
p.A57V	ACH-000986	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2222
p.M74R	ACH-000997	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.0833
p.R1806C	ACH-002396	Bone Cancer	CCLE	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.1944
p.R1806C	Sarc9371	bone	COSMIC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.1944
p.T1884A	ACN	autonomic ganglia	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation altering degron motif	0.6028
p.T1884A	HEC-1	endometrium	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation altering degron motif	0.6028
p.T1884A	HGC-27	stomach	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation altering degron motif	0.6028
p.T1884A	TE-4	oesophagus	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation altering degron motif	0.6028
p.T1884A	RERF-LC-FM	lung	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation altering degron motif	0.6028
p.T1884A	GAK	skin	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation altering degron motif	0.6028
p.R2060L	A172	central nervous system	COSMIC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.0556
p.R2060L	JVM-2	haematopoietic and lymphoid tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.0556
p.R2060L	D-245MG	central nervous system	COSMIC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.0556
p.G1879R	COLO-792	skin	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation altering degron motif	0.7568
p.R2060H	CESS	haematopoietic and lymphoid tissue	COSMIC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.0556
p.R2060H	MZ2-MEL	skin	COSMIC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.0556
p.R2060H	OAW-28	ovary	COSMIC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.0556
p.L2058M	SNU-C1	large intestine	COSMIC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.1111
p.V1890L	NCI-H196	lung	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation altering degron motif	0.6765
p.P1889H	KYSE-450	oesophagus	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	1877:1890	Mutation altering degron motif	0.7694
p.R1794C	Sarc9371	bone	COSMIC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation altering degron motif	0.8301
p.P1803H	EB2	haematopoietic and lymphoid tissue	COSMIC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.2778
p.A1811V	8-MG-BA	central nervous system	COSMIC	LAATPFMS	DEG_SCF_FBW7_1	1794:1801	Mutation rewiring degron network	0.0556
p.R2050H	SNU-1040	large intestine	COSMIC	ANTST	DEG_SPOP_SBC_1	2046:2050	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OTOG

UniProt ID: Q6ZRI0

Entrez ID: 340990

Protein name: Otogelin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OTOG in