DegronMD

Uniprot ID: Q6ZRI0

Source protein: Otogelin

Source gene: OTOG

Class: DEG_SCF_FBW7_1

Location: 1946:1951

E3 ligase: FBXW7

DEGRON score: 0.9555

ASA_SCORE: 78.8167

COIL: 0.78

CONS_SCORE: 0.4485

DSS_SCORE: 0.6355

HELIX: 0.0457

FCONS_SCORE: 0.9643

RIG_SCORE: 0.649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1947M	DO229016	COCA	ICGC	LTPATS	DEG_SCF_FBW7_1	0.7423
p.T1947M	DO234285	ESAD	ICGC	LTPATS	DEG_SCF_FBW7_1	0.7423
p.T1947M	DO229353	LAML	ICGC	LTPATS	DEG_SCF_FBW7_1	0.7423
p.T1947M	DO51043	LAML	ICGC	LTPATS	DEG_SCF_FBW7_1	0.7423
p.T1947M	DO230527	LUSC	ICGC	LTPATS	DEG_SCF_FBW7_1	0.7423
p.T1947M	DO230529	LUSC	ICGC	LTPATS	DEG_SCF_FBW7_1	0.7423
p.T1947M	DO230536	LUSC	ICGC	LTPATS	DEG_SCF_FBW7_1	0.7423
p.T1947M	DO230937	LUSC	ICGC	LTPATS	DEG_SCF_FBW7_1	0.7423
p.T1947M	DO231075	LUSC	ICGC	LTPATS	DEG_SCF_FBW7_1	0.7423
p.T1955M	DO228344	MALY	ICGC	LTPATS	DEG_SCF_FBW7_1	0.2222
p.T1955M	SIDM00846	Cervical Carcinoma	GDSC	LTPATS	DEG_SCF_FBW7_1	0.2222
p.E1960D	DO231284	PACA	ICGC	LTPATS	DEG_SCF_FBW7_1	0.0833
p.A1939T	SIDM00572	Gastric Carcinoma	GDSC	LTPATS	DEG_SCF_FBW7_1	0.1389
p.A1939T	ACH-000911	Gastric Cancer	CCLE	LTPATS	DEG_SCF_FBW7_1	0.1389
p.A1939T	NUGC-3	stomach	COSMIC	LTPATS	DEG_SCF_FBW7_1	0.1389
p.P1941L	ACH-000210	Bone Cancer	CCLE	LTPATS	DEG_SCF_FBW7_1	0.1944
p.P1941L	ACH-000865	Esophageal Cancer	CCLE	LTPATS	DEG_SCF_FBW7_1	0.1944
p.P1941L	ACH-001523	Skin Cancer	CCLE	LTPATS	DEG_SCF_FBW7_1	0.1944
p.P1941L	ACH-001623	Brain Cancer	CCLE	LTPATS	DEG_SCF_FBW7_1	0.1944
p.P1941L	ACH-002042	Thyroid Cancer	CCLE	LTPATS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRI0	Otogelin	DEG_SCF_FBW7_1	1946:1951	LTPATS	FBXW7	0.9555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons