DegronMD

Uniprot ID: Q6ZRI0

Source protein: Otogelin

Source gene: OTOG

Class: DEG_SCF_FBW7_2

Location: 1487:1493

E3 ligase: FBXW7

DEGRON score: 0.9058

ASA_SCORE: 75.1286

COIL: 0.6946

CONS_SCORE: 0.4698

DSS_SCORE: 0.8699

HELIX: 0.0649

FCONS_SCORE: 1.0577

RIG_SCORE: 0.567

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1488S	DO50970	LICA	ICGC	LPTPSDE	DEG_SCF_FBW7_2	0.5641
p.Q1485K	DO25189	LUAD	ICGC	LPTPSDE	DEG_SCF_FBW7_2	0.2778
p.P1483S	DO222516	MELA	ICGC	LPTPSDE	DEG_SCF_FBW7_2	0.2222
p.P1482S	SIDM00909	Melanoma	GDSC	LPTPSDE	DEG_SCF_FBW7_2	0.1944
p.P1482S	ACH-000644	Skin Cancer	CCLE	LPTPSDE	DEG_SCF_FBW7_2	0.1944
p.E1493K	ACH-000979	Prostate Cancer	CCLE	LPTPSDE	DEG_SCF_FBW7_2	0.7022
p.T1485M	ACH-000982	Colon/Colorectal Cancer	CCLE	LPTPSDE	DEG_SCF_FBW7_2	0.2778
p.T1485M	ACH-001345	Colon/Colorectal Cancer	CCLE	LPTPSDE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRI0	Otogelin	DEG_SCF_FBW7_2	1487:1493	LPTPSDE	FBXW7	0.9058	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons