DegronMD

Uniprot ID: Q6ZRI0

Source protein: Otogelin

Source gene: OTOG

Class: DEG_SCF_FBW7_1

Location: 1794:1801

E3 ligase: FBXW7

DEGRON score: 0.7575

ASA_SCORE: 88.3

COIL: 0.8139

CONS_SCORE: 0.4158

DSS_SCORE: 0.5245

HELIX: 0.0328

FCONS_SCORE: 0.9316

RIG_SCORE: 0.7281

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1788P	TCGA-AZ-4315	COAD	TCGA	LAATPFMS	DEG_SCF_FBW7_1	0.1667
p.S1788P	DO8842	COAD	ICGC	LAATPFMS	DEG_SCF_FBW7_1	0.1667
p.P1807S	TCGA-CK-5913	COAD	TCGA	LAATPFMS	DEG_SCF_FBW7_1	0.1667
p.P1807S	DO8826	COAD	ICGC	LAATPFMS	DEG_SCF_FBW7_1	0.1667
p.L1802I	TCGA-EO-A22R	UCEC	TCGA	LAATPFMS	DEG_SCF_FBW7_1	0.3056
p.L1802I	DO42713	UCEC	ICGC	LAATPFMS	DEG_SCF_FBW7_1	0.3056
p.D1792N	TCGA-Q1-A73O	CESC	TCGA	LAATPFMS	DEG_SCF_FBW7_1	0.2778
p.D1792N	DO51612	CESC	ICGC	LAATPFMS	DEG_SCF_FBW7_1	0.2778
p.A1790V	TCGA-VS-A8EL	CESC	TCGA	LAATPFMS	DEG_SCF_FBW7_1	0.2222
p.A1790V	DO51624	CESC	ICGC	LAATPFMS	DEG_SCF_FBW7_1	0.2222
p.A1784T	DO218693	GACA	ICGC	LAATPFMS	DEG_SCF_FBW7_1	0.0556
p.R1806H	DO15791	HNSC	ICGC	LAATPFMS	DEG_SCF_FBW7_1	0.1944
p.M1800I	DO228879	LICA	ICGC	LAATPFMS	DEG_SCF_FBW7_1	0.6507
p.D1792Y	DO229025	LICA	ICGC	LAATPFMS	DEG_SCF_FBW7_1	0.2778
p.P1792Q	ACH-000791	Lung Cancer	CCLE	LAATPFMS	DEG_SCF_FBW7_1	0.2778
p.R1806C	ACH-002396	Bone Cancer	CCLE	LAATPFMS	DEG_SCF_FBW7_1	0.1944
p.R1806C	Sarc9371	bone	COSMIC	LAATPFMS	DEG_SCF_FBW7_1	0.1944
p.R1794C	Sarc9371	bone	COSMIC	LAATPFMS	DEG_SCF_FBW7_1	0.8301
p.P1803H	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	LAATPFMS	DEG_SCF_FBW7_1	0.2778
p.A1811V	8-MG-BA	central_nervous_system	COSMIC	LAATPFMS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRI0	Otogelin	DEG_SCF_FBW7_1	1794:1801	LAATPFMS	FBXW7	0.7575	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons