DegronMD

Uniprot ID: Q6ZRI0

Source protein: Otogelin

Source gene: OTOG

Class: DEG_ODPH_VHL_1

Location: 1877:1890

E3 ligase: VHL

DEGRON score: 0.9435

ASA_SCORE: 80.6643

COIL: 0.8307

CONS_SCORE: 0.3701

DSS_SCORE: 0.4552

HELIX: 0.0342

FCONS_SCORE: 0.8902

RIG_SCORE: 0.6969

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1870K	TCGA-D5-5540	COAD	TCGA	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1389
p.Q1870K	DO8738	COAD	ICGC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1389
p.P1874H	TCGA-LL-A5YL	BRCA	TCGA	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.25
p.P1874H	DO44166	BRCA	ICGC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.25
p.G1883V	TCGA-SS-A7HO	COAD	TCGA	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.6421
p.G1883V	DO223705	COAD	ICGC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.6421
p.P1873S	DO222404	BTCA	ICGC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.2222
p.L1890R	DO229199	THCA	ICGC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.8428
p.A1871V	SIDM02039	Colorectal Carcinoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.T1896A	SIDM00057	Neuroblastoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.T1896A	SIDM00596	Endometrial Carcinoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.T1896A	SIDM00290	Gastric Carcinoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.T1896A	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.T1896A	SIDM00357	Small Cell Lung Carcinoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.T1896A	SIDM00543	Melanoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.T1896A	HGC-27	stomach	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.T1896A	ACN	autonomic_ganglia	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.T1896A	RERF-LC-FM	lung	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.T1896A	GAK	skin	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.T1896A	TE-4	oesophagus	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.T1896A	HEC-1	endometrium	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.1667
p.G1891R	SIDM00140	Melanoma	GDSC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.3056
p.G1891R	ACH-000968	Skin Cancer	CCLE	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.3056
p.G1891R	COLO-792	skin	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.3056
p.T1884A	ACN	autonomic_ganglia	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.6028
p.T1884A	HEC-1	endometrium	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.6028
p.T1884A	HGC-27	stomach	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.6028
p.T1884A	TE-4	oesophagus	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.6028
p.T1884A	RERF-LC-FM	lung	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.6028
p.T1884A	GAK	skin	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.6028
p.G1879R	COLO-792	skin	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.7568
p.V1890L	NCI-H196	lung	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.6765
p.P1889H	KYSE-450	oesophagus	COSMIC	IAPPAAGTAPGLLL	DEG_ODPH_VHL_1	0.7694

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPPAAGTAPGLLL

Degron related mutations and impact score

Drug responses associated with OTOG mutations

All proteins holding degron of IAPPAAGTAPGLLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRI0	Otogelin	DEG_ODPH_VHL_1	1877:1890	IAPPAAGTAPGLLL	VHL	0.9435	More...