DegronMD - Q9H361(PABPC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A477V	TCGA-AA-A010	COAD	TCGA	ANTST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.5825
p.Q482H	TCGA-AN-A046	BRCA	TCGA	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.3056
p.Q482H	DO1285	BRCA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.3056
p.R475H	TCGA-AP-A0LM	UCEC	TCGA	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.R475H	DO43306	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.T473M	TCGA-GV-A3JZ	BLCA	TCGA	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2222
p.T473M	TCGA-VQ-A8P5	STAD	TCGA	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2222
p.T473M	DO773	BLCA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2222
p.T473M	DO51763	STAD	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2222
p.T473M	SIDM00943	Pancreatic Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2222
p.T473M	ACH-000107	Pancreatic Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2222
p.T473M	Capan-2	pancreas	COSMIC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2222
p.V484M	DO48449	BLCA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.V484M	DO228926	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.V484M	DO228967	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.V484M	DO228972	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.V484M	DO229015	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.V484M	DO229034	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.V484M	DO229041	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.V484M	DO229046	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.R487C	DO48449	BLCA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.A489T	DO230347	COCA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1111
p.V470I	DO233797	GACA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1389
p.R475C	DO228965	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.R475C	DO228972	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.R475C	DO229034	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.R475C	DO229047	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.R475C	DO229046	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.R475C	DO229055	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.R469Q	DO229047	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1111
p.R469Q	DO229053	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1111
p.R469Q	DO229062	LICA	ICGC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1111
p.T479A	SIDM00333	Endometrial Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7139
p.T479A	ACH-000988	Endometrial/Uterine Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7139
p.T479A	MFE-319	endometrium	COSMIC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7139
p.S480L	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.8778
p.S480L	ACH-000852	Lung Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.8778
p.S480L	NCI-H1435	lung	COSMIC	ANTST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.8778

Kaplan plot for PABPC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PABPC3

UniProt ID: Q9H361

Entrez ID: 5042

Protein name: Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PABPC3 in