DegronMD

Uniprot ID: Q5XPI4

Source protein: E3 ubiquitin-protein ligase RNF123

Source gene: RNF123

Class: DEG_SPOP_SBC_1

Location: 1305:1309

E3 ligase: SPOP

DEGRON score: 0.618

ASA_SCORE: 73.68

COIL: 0.9092

CONS_SCORE: 0.3717

DSS_SCORE: 0.5557

HELIX: 0.0314

FCONS_SCORE: 0.9123

RIG_SCORE: 0.7155

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1311F	TCGA-B5-A0JY	UCEC	TCGA	ANTST	DEG_SPOP_SBC_1	0.2778
p.S1311F	DO43041	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	0.2778
p.S1297P	TCGA-CA-6717	COAD	TCGA	ANTST	DEG_SPOP_SBC_1	0.1111
p.S1297P	DO8264	COAD	ICGC	ANTST	DEG_SPOP_SBC_1	0.1111
p.S1312L	SIDM01372	Pancreatic Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	0.6944
p.S1312L	SIDM01735	Biliary Tract Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	0.6944
p.S1312L	ACH-000266	Pancreatic Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	0.6944
p.S1312L	ACH-000808	Bile Duct Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11940	Polyadenylate-binding protein 1	DEG_SPOP_SBC_1	483:487	ANTST	SPOP	0.9929	More...
Q5XPI4	E3 ubiquitin-protein ligase RNF123	DEG_SPOP_SBC_1	1305:1309	ANTST	SPOP	0.618	More...
Q6ZRI0	Otogelin	DEG_SPOP_SBC_1	2046:2050	ANTST	SPOP	0.621	More...
Q86WI1	Fibrocystin-L	DEG_SPOP_SBC_1	2964:2968	ANTST	SPOP	0.8314	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	DEG_SPOP_SBC_1	740:744	ANTST	SPOP	0.9875	More...
Q9H361	Polyadenylate-binding protein 3	DEG_SPOP_SBC_1	477:481	ANTST	SPOP	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons