DegronMD - Q5XPI4(RNF123)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R708C	TCGA-3N-A9WC	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1667
p.R708C	TCGA-D7-A6EV	STAD	TCGA	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1667
p.R708C	DO51234	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1667
p.R708C	DO50116	STAD	ICGC	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1667
p.S1311F	TCGA-B5-A0JY	UCEC	TCGA	ANTST	DEG_SPOP_SBC_1	1305:1309	Mutation rewiring degron network	0.2778
p.S1311F	DO43041	UCEC	ICGC	ANTST	DEG_SPOP_SBC_1	1305:1309	Mutation rewiring degron network	0.2778
p.S1297P	TCGA-CA-6717	COAD	TCGA	ANTST	DEG_SPOP_SBC_1	1305:1309	Mutation rewiring degron network	0.1111
p.S1297P	DO8264	COAD	ICGC	ANTST	DEG_SPOP_SBC_1	1305:1309	Mutation rewiring degron network	0.1111
p.P698L	TCGA-D3-A2J7	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation altering degron motif	0.7582
p.P698L	DO47695	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation altering degron motif	0.7582
p.R708P	TCGA-E2-A1BC	BRCA	TCGA	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1667
p.R708P	DO1270	BRCA	ICGC	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1667
p.A688V	TCGA-EO-A22U	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.0556
p.A688V	DO43755	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.0556
p.T709M	TCGA-HU-A4GQ	STAD	TCGA	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.T709M	DO227549	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.T709M	DO47767	STAD	ICGC	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.R697W	DO233140	GACA	ICGC	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.3056
p.A688T	SIDM00282	Colorectal Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.0556
p.A688T	ACH-000998	Colon/Colorectal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.0556
p.A688T	CW-2	large intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.0556
p.S1312L	SIDM01372	Pancreatic Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	1305:1309	Mutation blocking phosphorylation signal	0.6944
p.S1312L	SIDM01735	Biliary Tract Carcinoma	GDSC	ANTST	DEG_SPOP_SBC_1	1305:1309	Mutation blocking phosphorylation signal	0.6944
p.S1312L	ACH-000266	Pancreatic Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	1305:1309	Mutation blocking phosphorylation signal	0.6944
p.S1312L	ACH-000808	Bile Duct Cancer	CCLE	ANTST	DEG_SPOP_SBC_1	1305:1309	Mutation blocking phosphorylation signal	0.6944
p.R696L	ACH-000997	Colon/Colorectal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.2778
p.R696L	ACH-001061	Colon/Colorectal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.2778
p.D707N	HCT-116	large intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1944

Kaplan plot for RNF123 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF123

UniProt ID: Q5XPI4

Entrez ID: 63891

Protein name: E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) (RING-type E3 ubiquitin transferase RNF123)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF123 in