DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NPAPYTPPP
Uniprot ID:
Q9BUJ2
Source protein:
Heterogeneous nuclear ribonucleoprotein U-like protein 1
Source gene:
HNRNPUL1
Class:
CBL_PTK
Location:
793:801
E3 ligase:
CBL
DEGRON score:
0.9948
ASA_SCORE:
79.7556
COIL:
0.9758
CONS_SCORE:
0.2874
DSS_SCORE:
0.5783
HELIX:
0.0083
FCONS_SCORE:
0.8862
RIG_SCORE:
0.5704
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P811S
TCGA-2W-A8YY
CESC
TCGA
NPAPYTPPP
CBL_PTK
0.0556
p.P794T
TCGA-D3-A2J6
SKCM
TCGA
NPAPYTPPP
CBL_PTK
0.5919
p.P799L
TCGA-EE-A2M5
SKCM
TCGA
NPAPYTPPP
CBL_PTK
0.6471
p.A805S
TCGA-NC-A5HM
LUSC
TCGA
NPAPYTPPP
CBL_PTK
0.2222
p.A805T
SIDM00216
Colorectal Carcinoma
GDSC
NPAPYTPPP
CBL_PTK
0.2222
p.A805T
ACH-000989
Colon/Colorectal Cancer
CCLE
NPAPYTPPP
CBL_PTK
0.2222
p.A805T
SNU-175
large_intestine
COSMIC
NPAPYTPPP
CBL_PTK
0.2222
p.G791S
SIDM01078
Small Cell Lung Carcinoma
GDSC
NPAPYTPPP
CBL_PTK
0.2778
p.G791S
SIDM00364
B-Lymphoblastic Leukemia
GDSC
NPAPYTPPP
CBL_PTK
0.2778
p.Y789H
SIDM00537
Colorectal Carcinoma
GDSC
NPAPYTPPP
CBL_PTK
0.2222
p.Y789H
ACH-000982
Colon/Colorectal Cancer
CCLE
NPAPYTPPP
CBL_PTK
0.2222
p.Y789H
ACH-001345
Colon/Colorectal Cancer
CCLE
NPAPYTPPP
CBL_PTK
0.2222
p.Y789H
GP5d
large_intestine
COSMIC
NPAPYTPPP
CBL_PTK
0.2222
p.P800L
SIDM00217
Colorectal Carcinoma
GDSC
NPAPYTPPP
CBL_PTK
0.6471
p.P800L
ACH-000999
Colon/Colorectal Cancer
CCLE
NPAPYTPPP
CBL_PTK
0.6471
p.P800L
SNU-1040
large_intestine
COSMIC
NPAPYTPPP
CBL_PTK
0.6471
p.T797A
C-33-A
cervix
COSMIC
NPAPYTPPP
CBL_PTK
0.7139
Drug responses associated with HNRNPUL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPAPYTPPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BUJ2
Heterogeneous nuclear ribonucleoprotein U-like protein 1
CBL_PTK
793:801
NPAPYTPPP
CBL
0.9948
More...