DegronMD

Uniprot ID: Q9BUJ2

Source protein: Heterogeneous nuclear ribonucleoprotein U-like protein 1

Source gene: HNRNPUL1

Class: LIG_APCC_ABBA_1

Location: 83:88

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8585

ASA_SCORE: 99.55

COIL: 0.9447

CONS_SCORE: 0.3121

DSS_SCORE: 0.8803

HELIX: 0.0208

FCONS_SCORE: 1.0578

RIG_SCORE: 0.5634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T75I	TCGA-BT-A0YX	BLCA	TCGA	LQPHAE	LIG_APCC_ABBA_1	0.1111
p.R79P	DO228899	LICA	ICGC	LQPHAE	LIG_APCC_ABBA_1	0.2222
p.F84C	DO50931	LICA	ICGC	LQPHAE	LIG_APCC_ABBA_1	0.7108
p.D89Y	DO50931	LICA	ICGC	LQPHAE	LIG_APCC_ABBA_1	0.3056
p.P74S	DO35196	PACA	ICGC	LQPHAE	LIG_APCC_ABBA_1	0.0833
p.E88D	DO38715	STAD	ICGC	LQPHAE	LIG_APCC_ABBA_1	0.5647
p.Q96R	DO47867	STAD	ICGC	LQPHAE	LIG_APCC_ABBA_1	0.1111
p.P95H	DO40843	UCEC	ICGC	LQPHAE	LIG_APCC_ABBA_1	0.1389
p.A87P	SIDM00845	Burkitt's Lymphoma	GDSC	LQPHAE	LIG_APCC_ABBA_1	0.6392
p.E73K	ACH-002166	Skin Cancer	CCLE	LQPHAE	LIG_APCC_ABBA_1	0.0556
p.E73K	MZ7-mel	skin	COSMIC	LQPHAE	LIG_APCC_ABBA_1	0.0556
p.L98P	GP5d	large_intestine	COSMIC	LQPHAE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	LIG_APCC_ABBA_1	83:88	LQPHAE	APC,CDC20,FZR1	0.8585	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons