DegronMD

Uniprot ID: P37231

Source protein: Peroxisome proliferator-activated receptor gamma

Source gene: PPARG

Class: DEG_SCF_FBW7_2

Location: 73:79

E3 ligase: FBXW7

DEGRON score: 0.9793

ASA_SCORE: 78.1286

COIL: 0.9009

CONS_SCORE: 0.3851

DSS_SCORE: 0.272

HELIX: 0.0586

FCONS_SCORE: 1.2749

RIG_SCORE: 0.7404

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R85K	TCGA-DA-A1HW	SKCM	TCGA	ISTPHYE	DEG_SCF_FBW7_2	0.1667
p.P82A	TCGA-DK-AA71	BLCA	TCGA	ISTPHYE	DEG_SCF_FBW7_2	0.25
p.P88A	TCGA-DU-7006	LGG	TCGA	ISTPHYE	DEG_SCF_FBW7_2	0.0833
p.E79K	TCGA-EW-A1IZ	BRCA	TCGA	ISTPHYE	DEG_SCF_FBW7_2	0.7022
p.E79K	TCGA-W3-AA1V	SKCM	TCGA	ISTPHYE	DEG_SCF_FBW7_2	0.7022
p.D68H	DO49800	BLCA	ICGC	ISTPHYE	DEG_SCF_FBW7_2	0.1944
p.L69R	DO1118	BRCA	ICGC	ISTPHYE	DEG_SCF_FBW7_2	0.2222
p.V80A	DO230312	COCA	ICGC	ISTPHYE	DEG_SCF_FBW7_2	0.3056
p.P85S	DO220857	MELA	ICGC	ISTPHYE	DEG_SCF_FBW7_2	0.1667
p.S89Y	DO41020	UCEC	ICGC	ISTPHYE	DEG_SCF_FBW7_2	0.0556
p.T67A	SIDM00367	Small Cell Lung Carcinoma	GDSC	ISTPHYE	DEG_SCF_FBW7_2	0.1667
p.T67A	SBC-3	lung	COSMIC	ISTPHYE	DEG_SCF_FBW7_2	0.1667
p.I81F	SIDM00761	Small Cell Lung Carcinoma	GDSC	ISTPHYE	DEG_SCF_FBW7_2	0.2778
p.I81F	NCI-H196	lung	COSMIC	ISTPHYE	DEG_SCF_FBW7_2	0.2778
p.S72G	SIDM01560	Rhabdomyosarcoma	GDSC	ISTPHYE	DEG_SCF_FBW7_2	0.3056
p.D64Y	ACH-000201	Rhabdoid	CCLE	ISTPHYE	DEG_SCF_FBW7_2	0.0833
p.D64Y	ACH-001212	Rhabdoid	CCLE	ISTPHYE	DEG_SCF_FBW7_2	0.0833
p.S74C	ACH-000696	Ovarian Cancer	CCLE	ISTPHYE	DEG_SCF_FBW7_2	0.643
p.S84C	ACH-000934	Breast Cancer	CCLE	ISTPHYE	DEG_SCF_FBW7_2	0.1944
p.S84C	MDA-MB-361	breast	COSMIC	ISTPHYE	DEG_SCF_FBW7_2	0.1944
p.D64N	ACH-002338	Skin Cancer	CCLE	ISTPHYE	DEG_SCF_FBW7_2	0.0833
p.D64N	ACH-002510	Skin Cancer	CCLE	ISTPHYE	DEG_SCF_FBW7_2	0.0833
p.V68I	23132-87	stomach	COSMIC	ISTPHYE	DEG_SCF_FBW7_2	0.1944

Drug responses associated with PPARG mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01164	LGG\|glioma	p.A263V (No)	GDSC	FH535	5.4913
SIDM01164	LGG\|glioma	p.A263V (No)	GDSC	FH535	5.4913
SIDM01045	UCEC\|endometrium	p.L298fs*38 (No)	GDSC	FH535	2.9707
SIDM01045	UCEC\|endometrium	p.L298fs*38 (No)	GDSC	FH535	2.9707
SIDM00980	STAD\|stomach	p.V90I (Yes)	GDSC	FH535	3.642
SIDM00980	STAD\|stomach	p.V90I (Yes)	GDSC	FH535	3.642
SIDM00612	LGG\|glioma	p.I264M (No)	GDSC	FH535	23.4365
SIDM00612	LGG\|glioma	p.I264M (No)	GDSC	FH535	23.4365
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.S186fs*2 (No)	GDSC	FH535	19.962
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.S186fs*2 (No)	GDSC	FH535	19.962
SIDM00529	BRCA\|breast	p.V335L (No)	GDSC	FH535	6.986
SIDM00529	BRCA\|breast	p.V335L (No)	GDSC	FH535	6.986
SIDM00256	NB\|neuroblastoma	p.V48M (No)	GDSC	FH535	4.4189
SIDM00256	NB\|neuroblastoma	p.V48M (No)	GDSC	FH535	4.4189
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.E28K (No)	GDSC	FH535	6.5838
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.E28K (No)	GDSC	FH535	6.5838
SIDM01085	BLCA\|bladder	p.T475M (No)	GDSC	FH535	86.5513
SIDM01085	BLCA\|bladder	p.T475M (No)	GDSC	FH535	86.5513
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.E304K (No)	GDSC	FH535	6.8558
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.E304K (No)	GDSC	FH535	6.8558
SIDM00257	NB\|neuroblastoma	p.L480P (No)	GDSC	FH535	5.255
SIDM00257	NB\|neuroblastoma	p.L480P (No)	GDSC	FH535	5.255
SIDM00789	COREAD\|large_intestine	p.K450Q (No)	GDSC	FH535	6.3457
SIDM00789	COREAD\|large_intestine	p.K450Q (No)	GDSC	FH535	6.3457
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S370F (No)	GDSC	FH535	29.3362
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S370F (No)	GDSC	FH535	29.3362
SIDM01112	UNCLASSIFIED\|bone_other	p.V335L (No)	GDSC	FH535	5.9799
SIDM01112	UNCLASSIFIED\|bone_other	p.V335L (No)	GDSC	FH535	5.9799
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.L493P (No)	GDSC	FH535	5.3699
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.L493P (No)	GDSC	FH535	5.3699
SIDM00528	BRCA\|breast	p.S112C (No)	GDSC	FH535	2.7366
SIDM00528	BRCA\|breast	p.S112C (No)	GDSC	FH535	2.7366
SIDM00364	ALL\|lymphoblastic_leukemia	p.P255R (No)	GDSC	FH535	11.5572
SIDM00364	ALL\|lymphoblastic_leukemia	p.P255R (No)	GDSC	FH535	11.5572
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.V478L (No)	GDSC	FH535	3.8752
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.V478L (No)	GDSC	FH535	3.8752
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.I81F (Yes)	GDSC	FH535	32.4868
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.I81F (Yes)	GDSC	FH535	32.4868
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.T67A (Yes)	GDSC	FH535	0.5396
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.T67A (Yes)	GDSC	FH535	0.5396

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ISTPHYE

Degron related mutations and impact score

Drug responses associated with PPARG mutations

All proteins holding degron of ISTPHYE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37231	Peroxisome proliferator-activated receptor gamma	DEG_SCF_FBW7_2	73:79	ISTPHYE	FBXW7	0.9793	More...