DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NVSYTRQP
Uniprot ID:
Q96AW1
Source protein:
Vesicular, overexpressed in cancer, prosurvival protein 1
Source gene:
VOPP1
Class:
CBL_PTK
Location:
97:104
E3 ligase:
CBL
DEGRON score:
0.9589
ASA_SCORE:
85.1
COIL:
0.8615
CONS_SCORE:
0.9202
DSS_SCORE:
0.5844
HELIX:
0.0195
FCONS_SCORE:
1.2538
RIG_SCORE:
0.6832
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P88S
TCGA-04-1648
OV
TCGA
NVSYTRQP
CBL_PTK
0.0833
p.P89R
TCGA-77-6845
LUSC
TCGA
NVSYTRQP
CBL_PTK
0.1111
p.P107S
TCGA-BF-AAP2
SKCM
TCGA
NVSYTRQP
CBL_PTK
0.25
p.G108D
TCGA-BG-A0VZ
UCEC
TCGA
NVSYTRQP
CBL_PTK
0.2222
p.P88L
TCGA-D1-A167
UCEC
TCGA
NVSYTRQP
CBL_PTK
0.0833
p.P89S
TCGA-DA-A95V
SKCM
TCGA
NVSYTRQP
CBL_PTK
0.1111
p.A111D
TCGA-DI-A1BU
UCEC
TCGA
NVSYTRQP
CBL_PTK
0.1389
p.P104T
DO229041
LICA
ICGC
NVSYTRQP
CBL_PTK
0.7031
p.P104T
DO229006
LICA
ICGC
NVSYTRQP
CBL_PTK
0.7031
p.E99K
DO36556
READ
ICGC
NVSYTRQP
CBL_PTK
0.7022
p.E99K
DO43041
UCEC
ICGC
NVSYTRQP
CBL_PTK
0.7022
p.P87S
DO219478
SKCM
ICGC
NVSYTRQP
CBL_PTK
0.0556
p.G106D
DO42368
UCEC
ICGC
NVSYTRQP
CBL_PTK
0.2778
p.R102G
SIDM01157
Other Solid Cancers
GDSC
NVSYTRQP
CBL_PTK
0.6457
p.R102G
SW954
vulva
COSMIC
NVSYTRQP
CBL_PTK
0.6457
p.R93G
SW954
vulva
COSMIC
NVSYTRQP
CBL_PTK
0.2222
p.V113I
CW-2
large_intestine
COSMIC
NVSYTRQP
CBL_PTK
0.0833
p.R100G
SW954
vulva
COSMIC
NVSYTRQP
CBL_PTK
0.7568
p.T93M
HCC-33
lung
COSMIC
NVSYTRQP
CBL_PTK
0.2222
p.V101I
LN-229
central_nervous_system
COSMIC
NVSYTRQP
CBL_PTK
0.7076
p.P108S
NCI-H1975
lung
COSMIC
NVSYTRQP
CBL_PTK
0.2222
p.R99G
SW954
vulva
COSMIC
NVSYTRQP
CBL_PTK
0.7568
p.V105I
LN-229
central_nervous_system
COSMIC
NVSYTRQP
CBL_PTK
0.3056
p.T97M
HCC-33
lung
COSMIC
NVSYTRQP
CBL_PTK
0.7423
Drug responses associated with VOPP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NVSYTRQP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96AW1
Vesicular, overexpressed in cancer, prosurvival protein 1
CBL_PTK
97:104
NVSYTRQP
CBL
0.9589
More...