DegronMD

Uniprot ID: Q13310

Source protein: Polyadenylate-binding protein 4

Source gene: PABPC4

Class: DEG_COP1_1

Location: 491:502

E3 ligase: COP1

DEGRON score: 0.8943

ASA_SCORE: 67.0083

COIL: 0.846

CONS_SCORE: 0.239

DSS_SCORE: 0.4031

HELIX: 0.1029

FCONS_SCORE: 0.8953

RIG_SCORE: 0.7058

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R491H	TCGA-06-5416	GBM	TCGA	TDSCQSGGVPTA	DEG_COP1_1	0.8244
p.R491H	SIDM00837	Colorectal Carcinoma	GDSC	TDSCQSGGVPTA	DEG_COP1_1	0.8244
p.R491H	SW48	large_intestine	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	0.8244
p.D490Y	TCGA-33-4583	LUSC	TCGA	TDSCQSGGVPTA	DEG_COP1_1	0.3056
p.P489L	TCGA-33-4583	LUSC	TCGA	TDSCQSGGVPTA	DEG_COP1_1	0.2778
p.A493G	TCGA-61-1907	OV	TCGA	TDSCQSGGVPTA	DEG_COP1_1	0.754
p.A501V	TCGA-D3-A8GI	SKCM	TCGA	TDSCQSGGVPTA	DEG_COP1_1	0.6936
p.A502V	TCGA-DK-AA6M	BLCA	TCGA	TDSCQSGGVPTA	DEG_COP1_1	0.5825
p.P489Q	TCGA-EE-A2MK	SKCM	TCGA	TDSCQSGGVPTA	DEG_COP1_1	0.2778
p.G505V	TCGA-EY-A1GU	UCEC	TCGA	TDSCQSGGVPTA	DEG_COP1_1	0.25
p.G498V	TCGA-WY-A859	LGG	TCGA	TDSCQSGGVPTA	DEG_COP1_1	0.6421
p.G498W	TCGA-WY-A859	LGG	TCGA	TDSCQSGGVPTA	DEG_COP1_1	0.6714
p.R509C	DO51927	BLCA	ICGC	TDSCQSGGVPTA	DEG_COP1_1	0.1389
p.P500H	DO49800	BLCA	ICGC	TDSCQSGGVPTA	DEG_COP1_1	0.7694
p.A486V	DO219003	BLCA	ICGC	TDSCQSGGVPTA	DEG_COP1_1	0.1944
p.A510T	DO8730	COAD	ICGC	TDSCQSGGVPTA	DEG_COP1_1	0.1111
p.A510T	SNU-1040	large_intestine	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	0.1111
p.A501S	DO11986	GBM	ICGC	TDSCQSGGVPTA	DEG_COP1_1	0.7588
p.A498V	DO12700	GBM	ICGC	TDSCQSGGVPTA	DEG_COP1_1	0.6936
p.G482V	DO219859	LGG	ICGC	TDSCQSGGVPTA	DEG_COP1_1	0.0833
p.G482W	DO219859	LGG	ICGC	TDSCQSGGVPTA	DEG_COP1_1	0.0833
p.A485V	DO50284	SKCM	ICGC	TDSCQSGGVPTA	DEG_COP1_1	0.1667
p.R501C	DO51259	SKCM	ICGC	TDSCQSGGVPTA	DEG_COP1_1	0.8301
p.A510V	DO38192	STAD	ICGC	TDSCQSGGVPTA	DEG_COP1_1	0.1111
p.G489V	DO41518	UCEC	ICGC	TDSCQSGGVPTA	DEG_COP1_1	0.2778
p.R491G	SIDM00845	Burkitt's Lymphoma	GDSC	TDSCQSGGVPTA	DEG_COP1_1	0.7568
p.T481I	SIDM00704	Small Cell Lung Carcinoma	GDSC	TDSCQSGGVPTA	DEG_COP1_1	0.0556
p.T481I	SIDM01577	Plasma Cell Myeloma	GDSC	TDSCQSGGVPTA	DEG_COP1_1	0.0556
p.T481I	NCI-H211	lung	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	0.0556
p.L506V	SIDM00461	Acute Myeloid Leukemia	GDSC	TDSCQSGGVPTA	DEG_COP1_1	0.2222
p.Q511H	SIDM01617	Endometrial Carcinoma	GDSC	TDSCQSGGVPTA	DEG_COP1_1	0.0833
p.A481S	ACH-000945	Lung Cancer	CCLE	TDSCQSGGVPTA	DEG_COP1_1	0.0556
p.A481S	NCI-H650	lung	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	0.0556
p.R489W	ACH-000963	Colon/Colorectal Cancer	CCLE	TDSCQSGGVPTA	DEG_COP1_1	0.2778
p.R489W	CCK-81	large_intestine	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	0.2778
p.Q495H	ACH-000994	Endometrial/Uterine Cancer	CCLE	TDSCQSGGVPTA	DEG_COP1_1	0.647
p.A481T	ACH-000999	Colon/Colorectal Cancer	CCLE	TDSCQSGGVPTA	DEG_COP1_1	0.0556
p.A481T	SNU-1040	large_intestine	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	0.0556
p.A497S	NCI-H650	lung	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	0.7588
p.R505W	CCK-81	large_intestine	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	0.25
p.A510S	NCI-H650	lung	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	0.1111
p.A497T	SNU-1040	large_intestine	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TDSCQSGGVPTA

Degron related mutations and impact score

Drug responses associated with PABPC4 mutations

All proteins holding degron of TDSCQSGGVPTA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13310	Polyadenylate-binding protein 4	DEG_COP1_1	491:502	TDSCQSGGVPTA	COP1	0.8943	More...