DegronMD

Uniprot ID: O94915

Source protein: Protein furry homolog-like

Source gene: FRYL

Class: DEG_APCC_KENBOX_2

Location: 1500:1504

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9725

ASA_SCORE: 99.74

COIL: 0.7362

CONS_SCORE: 0.2687

DSS_SCORE: 0.5348

HELIX: 0.1634

FCONS_SCORE: 1.0022

RIG_SCORE: 0.744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1507N	TCGA-75-5126	LUAD	TCGA	IKENI	DEG_APCC_KENBOX_2	0.25
p.S1507N	DO23711	LUAD	ICGC	IKENI	DEG_APCC_KENBOX_2	0.25
p.D1492Y	TCGA-AX-A05Z	UCEC	TCGA	IKENI	DEG_APCC_KENBOX_2	0.1111
p.D1492Y	DO40884	UCEC	ICGC	IKENI	DEG_APCC_KENBOX_2	0.1111
p.L1511P	TCGA-B5-A11J	UCEC	TCGA	IKENI	DEG_APCC_KENBOX_2	0.1389
p.L1511P	DO43698	UCEC	ICGC	IKENI	DEG_APCC_KENBOX_2	0.1389
p.E1506D	TCGA-CR-7395	HNSC	TCGA	IKENI	DEG_APCC_KENBOX_2	0.2778
p.E1506D	DO14274	HNSC	ICGC	IKENI	DEG_APCC_KENBOX_2	0.2778
p.D1496N	DO228483	BRCA	ICGC	IKENI	DEG_APCC_KENBOX_2	0.2222
p.D1496N	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	IKENI	DEG_APCC_KENBOX_2	0.2222
p.D1496N	ACH-000813	Lung Cancer	CCLE	IKENI	DEG_APCC_KENBOX_2	0.2222
p.N1494K	DO222468	BTCA	ICGC	IKENI	DEG_APCC_KENBOX_2	0.1667
p.I1500V	SIDM00212	Glioblastoma	GDSC	IKENI	DEG_APCC_KENBOX_2	0.5965
p.I1500V	ACH-000464	Brain Cancer	CCLE	IKENI	DEG_APCC_KENBOX_2	0.5965
p.I1500V	CAS-1	central_nervous_system	COSMIC	IKENI	DEG_APCC_KENBOX_2	0.5965
p.N1497I	SIDM01248	Thyroid Gland Carcinoma	GDSC	IKENI	DEG_APCC_KENBOX_2	0.25
p.N1497I	SIDM00042	Pancreatic Carcinoma	GDSC	IKENI	DEG_APCC_KENBOX_2	0.25
p.N1497I	SIDM00063	Melanoma	GDSC	IKENI	DEG_APCC_KENBOX_2	0.25
p.N1497I	SIDM01009	Neuroblastoma	GDSC	IKENI	DEG_APCC_KENBOX_2	0.25
p.N1497I	SIDM00699	Small Cell Lung Carcinoma	GDSC	IKENI	DEG_APCC_KENBOX_2	0.25
p.N1497I	SIDM01167	Thyroid Gland Carcinoma	GDSC	IKENI	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94915	Protein furry homolog-like	DEG_APCC_KENBOX_2	1500:1504	IKENI	APC,CDC20,FZR1	0.9725	More...
Q5U5Z8	Cytosolic carboxypeptidase 2	DEG_APCC_KENBOX_2	188:192	IKENI	APC,CDC20,FZR1	0.7359	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons