DegronMD - Q5U5Z8(AGBL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C185S	TCGA-2F-A9KW	BLCA	TCGA	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.25
p.C185S	DO51864	BLCA	ICGC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.25
p.V187F	TCGA-33-AASB	LUSC	TCGA	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.3056
p.V187F	DO219125	LUSC	ICGC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.3056
p.E184Q	TCGA-77-A5G8	LUSC	TCGA	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.2222
p.E184Q	DO50099	LUSC	ICGC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.2222
p.N191S	TCGA-AX-A2HD	UCEC	TCGA	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation altering degron motif	0.7069
p.N191S	DO42608	UCEC	ICGC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation altering degron motif	0.7069
p.W197L	TCGA-EE-A3AC	SKCM	TCGA	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.1944
p.W197L	DO37631	SKCM	ICGC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.1944
p.P199L	TCGA-FW-A3R5	SKCM	TCGA	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.1389
p.P199L	DO37406	SKCM	ICGC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.1389
p.P202Q	DO229037	LICA	ICGC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.0556
p.P200H	DO229041	LICA	ICGC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.1111
p.P202S	DO48700	LIRI	ICGC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.0556
p.W197C	DO229216	THCA	ICGC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.1944
p.H193Q	SIDM00679	Cervical Carcinoma	GDSC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.3056
p.H193Q	HT-3	cervix	COSMIC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.3056
p.I196V	ACH-000727	Lung Cancer	CCLE	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.2222
p.I196V	NCI-H2066	lung	COSMIC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation rewiring degron network	0.2222
p.L191F	ACH-000843	Lung Cancer	CCLE	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation altering degron motif	0.6981
p.L191F	HARA	lung	COSMIC	IKENI	DEG_APCC_KENBOX_2	188:192	Mutation altering degron motif	0.6981

Kaplan plot for AGBL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AGBL2

UniProt ID: Q5U5Z8

Entrez ID: 79841

Protein name: Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) (Protein deglutamylase CCP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AGBL2 in