DegronMD

Uniprot ID: Q5U5Z8

Source protein: Cytosolic carboxypeptidase 2

Source gene: AGBL2

Class: DEG_APCC_KENBOX_2

Location: 188:192

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7359

ASA_SCORE: 77.22

COIL: 0.8368

CONS_SCORE: 0.4572

DSS_SCORE: 0.2409

HELIX: 0.0448

FCONS_SCORE: 1.0599

RIG_SCORE: 0.793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C185S	TCGA-2F-A9KW	BLCA	TCGA	IKENI	DEG_APCC_KENBOX_2	0.25
p.C185S	DO51864	BLCA	ICGC	IKENI	DEG_APCC_KENBOX_2	0.25
p.V187F	TCGA-33-AASB	LUSC	TCGA	IKENI	DEG_APCC_KENBOX_2	0.3056
p.V187F	DO219125	LUSC	ICGC	IKENI	DEG_APCC_KENBOX_2	0.3056
p.E184Q	TCGA-77-A5G8	LUSC	TCGA	IKENI	DEG_APCC_KENBOX_2	0.2222
p.E184Q	DO50099	LUSC	ICGC	IKENI	DEG_APCC_KENBOX_2	0.2222
p.N191S	TCGA-AX-A2HD	UCEC	TCGA	IKENI	DEG_APCC_KENBOX_2	0.7069
p.N191S	DO42608	UCEC	ICGC	IKENI	DEG_APCC_KENBOX_2	0.7069
p.W197L	TCGA-EE-A3AC	SKCM	TCGA	IKENI	DEG_APCC_KENBOX_2	0.1944
p.W197L	DO37631	SKCM	ICGC	IKENI	DEG_APCC_KENBOX_2	0.1944
p.P199L	TCGA-FW-A3R5	SKCM	TCGA	IKENI	DEG_APCC_KENBOX_2	0.1389
p.P199L	DO37406	SKCM	ICGC	IKENI	DEG_APCC_KENBOX_2	0.1389
p.P202Q	DO229037	LICA	ICGC	IKENI	DEG_APCC_KENBOX_2	0.0556
p.P200H	DO229041	LICA	ICGC	IKENI	DEG_APCC_KENBOX_2	0.1111
p.P202S	DO48700	LIRI	ICGC	IKENI	DEG_APCC_KENBOX_2	0.0556
p.W197C	DO229216	THCA	ICGC	IKENI	DEG_APCC_KENBOX_2	0.1944
p.H193Q	SIDM00679	Cervical Carcinoma	GDSC	IKENI	DEG_APCC_KENBOX_2	0.3056
p.H193Q	HT-3	cervix	COSMIC	IKENI	DEG_APCC_KENBOX_2	0.3056
p.I196V	ACH-000727	Lung Cancer	CCLE	IKENI	DEG_APCC_KENBOX_2	0.2222
p.I196V	NCI-H2066	lung	COSMIC	IKENI	DEG_APCC_KENBOX_2	0.2222
p.L191F	ACH-000843	Lung Cancer	CCLE	IKENI	DEG_APCC_KENBOX_2	0.6981
p.L191F	HARA	lung	COSMIC	IKENI	DEG_APCC_KENBOX_2	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94915	Protein furry homolog-like	DEG_APCC_KENBOX_2	1500:1504	IKENI	APC,CDC20,FZR1	0.9725	More...
Q5U5Z8	Cytosolic carboxypeptidase 2	DEG_APCC_KENBOX_2	188:192	IKENI	APC,CDC20,FZR1	0.7359	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons