DegronMD

Uniprot ID: O94915

Source protein: Protein furry homolog-like

Source gene: FRYL

Class: DEG_APCC_DBOX_1

Location: 2451:2459

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9578

ASA_SCORE: 75.9556

COIL: 0.7147

CONS_SCORE: 0.2903

DSS_SCORE: 0.4042

HELIX: 0.1736

FCONS_SCORE: 0.91

RIG_SCORE: 0.7416

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2451C	TCGA-06-5416	GBM	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.R2451C	TCGA-AA-A010	COAD	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.R2451C	TCGA-F5-6814	READ	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.R2451C	TCGA-FI-A2D0	UCEC	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.R2451C	DO10880	GBM	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.R2451C	DO36556	READ	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.R2451C	DO43891	UCEC	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.R2451C	SIDM01043	Other Sarcomas	GDSC	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.R2451C	SIDM00193	Colorectal Carcinoma	GDSC	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.R2451C	ACH-000913	Endometrial/Uterine Cancer	CCLE	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.R2451C	ACH-000991	Colon/Colorectal Cancer	CCLE	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.R2451C	SNU-81	large_intestine	COSMIC	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.R2451C	ESS-1	endometrium	COSMIC	RRRSLDSID	DEG_APCC_DBOX_1	0.719
p.D2462N	TCGA-A5-A2K5	UCEC	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	0.25
p.D2462N	DO41379	UCEC	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	0.25
p.D2456N	TCGA-DK-A1AC	BLCA	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	0.5821
p.D2456N	DO514	BLCA	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	0.5821
p.F2446L	TCGA-KH-A6WC	ESCA	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	0.1944
p.V2450G	DO6458	CLLE	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	0.3056
p.V2450G	DO45129	LIRI	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	0.3056
p.D2444G	DO230311	COCA	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	0.1389
p.R2453H	SIDM00534	Colorectal Carcinoma	GDSC	RRRSLDSID	DEG_APCC_DBOX_1	0.7133
p.R2453H	ACH-000986	Colon/Colorectal Cancer	CCLE	RRRSLDSID	DEG_APCC_DBOX_1	0.7133
p.R2453H	HT-115	large_intestine	COSMIC	RRRSLDSID	DEG_APCC_DBOX_1	0.7133
p.E2468K	ACH-001569	Skin Cancer	CCLE	RRRSLDSID	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94915	Protein furry homolog-like	DEG_APCC_DBOX_1	2451:2459	RRRSLDSID	APC,CDC20,FZR1	0.9578	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRSLDSID

Degron related mutations and impact score

Drug responses associated with FRYL mutations

All proteins holding degron of RRRSLDSID