DegronMD

Uniprot ID: O94915

Source protein: Protein furry homolog-like

Source gene: FRYL

Class: DEG_SPOP_SBC_1

Location: 97:101

E3 ligase: SPOP

DEGRON score: 0.926

ASA_SCORE: 88.16

COIL: 0.8578

CONS_SCORE: 0.3095

DSS_SCORE: 0.608

HELIX: 0.113

FCONS_SCORE: 1.0856

RIG_SCORE: 0.6433

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R96K	TCGA-17-Z016	LUAD	TCGA	PRSST	DEG_SPOP_SBC_1	0.3056
p.R98W	TCGA-19-5956	GBM	TCGA	PRSST	DEG_SPOP_SBC_1	0.7523
p.R98W	DO13863	GBM	ICGC	PRSST	DEG_SPOP_SBC_1	0.7523
p.T88M	TCGA-BR-4370	STAD	TCGA	PRSST	DEG_SPOP_SBC_1	0.0833
p.T88M	DO223048	ESCA	ICGC	PRSST	DEG_SPOP_SBC_1	0.0833
p.T88M	DO38499	STAD	ICGC	PRSST	DEG_SPOP_SBC_1	0.0833
p.G87R	TCGA-D5-6924	COAD	TCGA	PRSST	DEG_SPOP_SBC_1	0.0556
p.G87R	DO7922	COAD	ICGC	PRSST	DEG_SPOP_SBC_1	0.0556
p.R110C	TCGA-DU-6392	LGG	TCGA	PRSST	DEG_SPOP_SBC_1	0.0833
p.R110C	DO22237	LGG	ICGC	PRSST	DEG_SPOP_SBC_1	0.0833
p.R101Q	DO51883	BLCA	ICGC	PRSST	DEG_SPOP_SBC_1	0.7329
p.R101Q	DO1263	BRCA	ICGC	PRSST	DEG_SPOP_SBC_1	0.7329
p.R101Q	DO10172	COAD	ICGC	PRSST	DEG_SPOP_SBC_1	0.7329
p.R101Q	DO41133	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	0.7329
p.R87C	DO8730	COAD	ICGC	PRSST	DEG_SPOP_SBC_1	0.0556
p.S100I	DO223155	ESCA	ICGC	PRSST	DEG_SPOP_SBC_1	0.8453
p.R87S	DO228974	LICA	ICGC	PRSST	DEG_SPOP_SBC_1	0.0556
p.T88K	DO229035	LICA	ICGC	PRSST	DEG_SPOP_SBC_1	0.0833
p.E94V	DO228338	MALY	ICGC	PRSST	DEG_SPOP_SBC_1	0.25
p.E94V	SIDM00948	Burkitt's Lymphoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.25
p.E94V	ACH-002232	Lymphoma	CCLE	PRSST	DEG_SPOP_SBC_1	0.25
p.E94V	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PRSST	DEG_SPOP_SBC_1	0.25
p.R106C	DO222743	MELA	ICGC	PRSST	DEG_SPOP_SBC_1	0.1944
p.S90I	DO37631	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	0.1389
p.P97L	DO47368	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	0.7582
p.G105R	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.2222
p.G105R	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	PRSST	DEG_SPOP_SBC_1	0.2222
p.Y95C	ACH-001510	Head and Neck Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JNW5	UHRF1-binding protein 1-like	DEG_SPOP_SBC_1	1328:1332	PRSST	SPOP	0.9595	More...
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.9128	More...
O00512	B-cell CLL/lymphoma 9 protein	DEG_SPOP_SBC_1	151:155	PRSST	SPOP	0.9984	More...
O94915	Protein furry homolog-like	DEG_SPOP_SBC_1	97:101	PRSST	SPOP	0.926	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	545:549	PRSST	SPOP	0.9681	More...
P48764	Sodium/hydrogen exchanger 3	DEG_SPOP_SBC_1	574:578	PRSST	SPOP	0.807	More...
Q8IZP1	TBC1 domain family member 3	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q8TD19	Serine/threonine-protein kinase Nek9	DEG_SPOP_SBC_1	329:333	PRSST	SPOP	0.8086	More...
Q8WTW3	Conserved oligomeric Golgi complex subunit 1	DEG_SPOP_SBC_1	888:892	PRSST	SPOP	0.8806	More...
Q6DHY5	TBC1 domain family member 3G	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q9Y5G5	Protocadherin gamma-A8	DEG_SPOP_SBC_1	221:225	PRSST	SPOP	0.8172	More...
A6NDS4	TBC1 domain family member 3B	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
A6NER0	TBC1 domain family member 3F	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
P0C7X1	TBC1 domain family member 3H	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q6IPX1	TBC1 domain family member 3C	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9745	More...
Q9NVM1	Protein eva-1 homolog B	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.6927	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	714:718	PRSST	SPOP	0.764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSST

Degron related mutations and impact score

Drug responses associated with FRYL mutations

All proteins holding degron of PRSST