DegronMD

Uniprot ID: A6H8Y1

Source protein: Transcription factor TFIIIB component B'' homolog

Source gene: BDP1

Class: DEG_SPOP_SBC_1

Location: 68:72

E3 ligase: SPOP

DEGRON score: 0.9128

ASA_SCORE: 96.06

COIL: 0.9196

CONS_SCORE: 0.3124

DSS_SCORE: 0.821

HELIX: 0.0462

FCONS_SCORE: 0.8547

RIG_SCORE: 0.5857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E65D	TCGA-06-1802	GBM	TCGA	PRSST	DEG_SPOP_SBC_1	0.25
p.E65D	DO12100	GBM	ICGC	PRSST	DEG_SPOP_SBC_1	0.25
p.D80Y	TCGA-A5-A2K5	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	0.1111
p.D80Y	DO41379	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	0.1111
p.S71I	TCGA-BF-A1PZ	SKCM	TCGA	PRSST	DEG_SPOP_SBC_1	0.7341
p.M59I	DO7962	COAD	ICGC	PRSST	DEG_SPOP_SBC_1	0.0833
p.M59V	DO23210	LINC	ICGC	PRSST	DEG_SPOP_SBC_1	0.0833
p.M59V	DO23274	LINC	ICGC	PRSST	DEG_SPOP_SBC_1	0.0833
p.E63Q	DO27074	LUSC	ICGC	PRSST	DEG_SPOP_SBC_1	0.1944
p.P82Q	DO50279	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	0.0556
p.P69Q	DO47636	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	0.7035
p.V77A	DO229272	THCA	ICGC	PRSST	DEG_SPOP_SBC_1	0.1944
p.P69A	DO40526	THCA	ICGC	PRSST	DEG_SPOP_SBC_1	0.7503
p.S71N	SIDM00516	Melanoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.7069
p.S71N	MZ7-mel	skin	COSMIC	PRSST	DEG_SPOP_SBC_1	0.7069
p.E65K	SIDM00158	Glioblastoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.25
p.E62K	SIDM00500	Colorectal Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.1667
p.E62K	ACH-000959	Colon/Colorectal Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JNW5	UHRF1-binding protein 1-like	DEG_SPOP_SBC_1	1328:1332	PRSST	SPOP	0.9595	More...
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.9128	More...
O00512	B-cell CLL/lymphoma 9 protein	DEG_SPOP_SBC_1	151:155	PRSST	SPOP	0.9984	More...
O94915	Protein furry homolog-like	DEG_SPOP_SBC_1	97:101	PRSST	SPOP	0.926	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	545:549	PRSST	SPOP	0.9681	More...
P48764	Sodium/hydrogen exchanger 3	DEG_SPOP_SBC_1	574:578	PRSST	SPOP	0.807	More...
Q8IZP1	TBC1 domain family member 3	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q8TD19	Serine/threonine-protein kinase Nek9	DEG_SPOP_SBC_1	329:333	PRSST	SPOP	0.8086	More...
Q8WTW3	Conserved oligomeric Golgi complex subunit 1	DEG_SPOP_SBC_1	888:892	PRSST	SPOP	0.8806	More...
Q6DHY5	TBC1 domain family member 3G	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q9Y5G5	Protocadherin gamma-A8	DEG_SPOP_SBC_1	221:225	PRSST	SPOP	0.8172	More...
A6NDS4	TBC1 domain family member 3B	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
A6NER0	TBC1 domain family member 3F	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
P0C7X1	TBC1 domain family member 3H	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q6IPX1	TBC1 domain family member 3C	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9745	More...
Q9NVM1	Protein eva-1 homolog B	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.6927	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	714:718	PRSST	SPOP	0.764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons