DegronMD

Uniprot ID: A0JNW5

Source protein: UHRF1-binding protein 1-like

Source gene: UHRF1BP1L

Class: DEG_SPOP_SBC_1

Location: 1328:1332

E3 ligase: SPOP

DEGRON score: 0.9595

ASA_SCORE: 78.46

COIL: 0.93

CONS_SCORE: 0.3287

DSS_SCORE: 0.5213

HELIX: 0.0382

FCONS_SCORE: 0.8392

RIG_SCORE: 0.6535

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1338T	TCGA-AX-A0J1	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	0.1667
p.R1329Q	TCGA-BS-A0UV	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	0.6218
p.R1329Q	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PRSST	DEG_SPOP_SBC_1	0.6218
p.R1329Q	SIDM00760	Small Cell Lung Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.6218
p.R1329Q	ACH-000729	Lung Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	0.6218
p.R1329Q	ACH-002275	Leukemia	CCLE	PRSST	DEG_SPOP_SBC_1	0.6218
p.R1329Q	NCI-H1963	lung	COSMIC	PRSST	DEG_SPOP_SBC_1	0.6218
p.R1329Q	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PRSST	DEG_SPOP_SBC_1	0.6218
p.P1337S	TCGA-D1-A167	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	0.1944
p.P1339T	TCGA-D3-A2JP	SKCM	TCGA	PRSST	DEG_SPOP_SBC_1	0.1389
p.D1326N	TCGA-DS-A0VK	CESC	TCGA	PRSST	DEG_SPOP_SBC_1	0.2778
p.E1336Q	SIDM01021	Glioblastoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.2222
p.E1336Q	ACH-002223	Brain Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	0.2222
p.E1336Q	D-245MG	central_nervous_system	COSMIC	PRSST	DEG_SPOP_SBC_1	0.2222
p.R1329G	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.6457
p.R1329G	ACH-000980	Lung Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	0.6457
p.R1329G	NCI-H1155	lung	COSMIC	PRSST	DEG_SPOP_SBC_1	0.6457
p.P1328S	SIDM00493	Other Solid Cancers	GDSC	PRSST	DEG_SPOP_SBC_1	0.6752
p.P1328S	SIDM01173	Rhabdomyosarcoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.6752
p.N1322H	SIDM01588	Endometrial Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	0.1667
p.N1322H	ACH-000993	Endometrial/Uterine Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JNW5	UHRF1-binding protein 1-like	DEG_SPOP_SBC_1	1328:1332	PRSST	SPOP	0.9595	More...
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.9128	More...
O00512	B-cell CLL/lymphoma 9 protein	DEG_SPOP_SBC_1	151:155	PRSST	SPOP	0.9984	More...
O94915	Protein furry homolog-like	DEG_SPOP_SBC_1	97:101	PRSST	SPOP	0.926	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	545:549	PRSST	SPOP	0.9681	More...
P48764	Sodium/hydrogen exchanger 3	DEG_SPOP_SBC_1	574:578	PRSST	SPOP	0.807	More...
Q8IZP1	TBC1 domain family member 3	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q8TD19	Serine/threonine-protein kinase Nek9	DEG_SPOP_SBC_1	329:333	PRSST	SPOP	0.8086	More...
Q8WTW3	Conserved oligomeric Golgi complex subunit 1	DEG_SPOP_SBC_1	888:892	PRSST	SPOP	0.8806	More...
Q6DHY5	TBC1 domain family member 3G	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q9Y5G5	Protocadherin gamma-A8	DEG_SPOP_SBC_1	221:225	PRSST	SPOP	0.8172	More...
A6NDS4	TBC1 domain family member 3B	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
A6NER0	TBC1 domain family member 3F	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
P0C7X1	TBC1 domain family member 3H	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q6IPX1	TBC1 domain family member 3C	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9745	More...
Q9NVM1	Protein eva-1 homolog B	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.6927	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	714:718	PRSST	SPOP	0.764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons