DegronMD - P48764(SLC9A3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V570M	TCGA-AA-3492	COAD	TCGA	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation altering degron motif	0.6097
p.R552H	TCGA-AA-3864	COAD	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation altering degron motif	0.7133
p.S545G	TCGA-AJ-A3BH	UCEC	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation blocking phosphorylation signal	0.5833
p.R575Q	TCGA-AX-A2HC	UCEC	TCGA	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation altering degron motif	0.6218
p.R575Q	TCGA-AX-A2HC	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.6218
p.R553C	TCGA-DA-A95Z	SKCM	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation altering degron motif	0.8301
p.A543T	TCGA-DU-6392	LGG	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.0833
p.V568I	TCGA-EE-A2MR	SKCM	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.1111
p.V568I	TCGA-EE-A2MR	SKCM	TCGA	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.2778
p.V568I	TCGA-EE-A2MR	SKCM	TCGA	PRSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.S545R	TCGA-FI-A2F4	UCEC	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation blocking phosphorylation signal	0.5833
p.S561Y	TCGA-FV-A2QR	LIHC	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.3056
p.S561Y	TCGA-FV-A2QR	LIHC	TCGA	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.0833
p.D542N	TCGA-R5-A7O7	STAD	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.0556
p.R553H	TCGA-VQ-A8P2	STAD	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation altering degron motif	0.8244
p.R543H	DO8490	COAD	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.0833
p.V561M	DO8224	COAD	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.3056
p.V561M	DO8224	COAD	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.0833
p.E580Q	DO52079	HNSC	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.25
p.E580Q	DO52079	HNSC	ICGC	PRSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2778
p.V585A	DO22237	LGG	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.1111
p.V585A	DO22237	LGG	ICGC	PRSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1389
p.F563L	DO228974	LICA	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation blocking phosphorylation signal	0.6944
p.F563L	DO228974	LICA	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation blocking phosphorylation signal	0.5833
p.N560K	DO229045	LICA	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation altering degron motif	0.6918
p.S552Y	DO22837	LIHC	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation altering degron motif	0.712
p.E580K	DO25847	LUAD	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.25
p.E580K	DO25847	LUAD	ICGC	PRSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2778
p.V559I	DO37819	SKCM	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation altering degron motif	0.7076
p.R544C	DO219481	SKCM	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.1111
p.R544H	DO51761	STAD	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.1111
p.A584T	DO229253	THCA	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.1389
p.A584T	DO229253	THCA	ICGC	PRSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.R566Q	DO41572	UCEC	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.1667
p.R566Q	DO41572	UCEC	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.2222
p.R566Q	DO41572	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.N581Y	DO41903	UCEC	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.2222
p.N581Y	DO41903	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.25
p.D542Y	SIDM00789	Colorectal Carcinoma	GDSC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.0556
p.D542Y	ACH-000997	Colon/Colorectal Cancer	CCLE	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.0556
p.D542Y	HCT-15	large intestine	COSMIC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.0556
p.T573K	SIDM00223	Small Cell Lung Carcinoma	GDSC	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation altering degron motif	0.7306
p.T573K	ACH-002144	Lung Cancer	CCLE	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation altering degron motif	0.7306
p.T573K	IST-SL1	lung	COSMIC	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation altering degron motif	0.7306
p.S561F	SIDM01735	Biliary Tract Carcinoma	GDSC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.3056
p.S561F	SIDM01735	Biliary Tract Carcinoma	GDSC	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.0833
p.S561F	ACH-000808	Bile Duct Cancer	CCLE	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation rewiring degron network	0.3056
p.S561F	ACH-000808	Bile Duct Cancer	CCLE	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.0833
p.T564K	IST-SL1	lung	COSMIC	RRGSLAFIR	DEG_APCC_DBOX_1	552:560	Mutation blocking phosphorylation signal	0.6667
p.T564K	IST-SL1	lung	COSMIC	VDFTPRSS	DEG_SCF_FBW7_1	570:577	Mutation blocking phosphorylation signal	0.6111
p.T564K	IST-SL1	lung	COSMIC	PRSST	DEG_SPOP_SBC_1	574:578	Mutation blocking phosphorylation signal	0.5

Kaplan plot for SLC9A3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC9A3

UniProt ID: P48764

Entrez ID: 6550

Protein name: Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC9A3 in