DegronMD

Uniprot ID: P48764

Source protein: Sodium/hydrogen exchanger 3

Source gene: SLC9A3

Class: DEG_SPOP_SBC_1

Location: 574:578

E3 ligase: SPOP

DEGRON score: 0.807

ASA_SCORE: 86.58

COIL: 0.8672

CONS_SCORE: 0.3637

DSS_SCORE: 0.2242

HELIX: 0.1004

FCONS_SCORE: 1.1517

RIG_SCORE: 0.7516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R575Q	TCGA-AX-A2HC	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	0.6218
p.V568I	TCGA-EE-A2MR	SKCM	TCGA	PRSST	DEG_SPOP_SBC_1	0.1667
p.E580Q	DO52079	HNSC	ICGC	PRSST	DEG_SPOP_SBC_1	0.2778
p.V585A	DO22237	LGG	ICGC	PRSST	DEG_SPOP_SBC_1	0.1389
p.E580K	DO25847	LUAD	ICGC	PRSST	DEG_SPOP_SBC_1	0.2778
p.A584T	DO229253	THCA	ICGC	PRSST	DEG_SPOP_SBC_1	0.1667
p.R566Q	DO41572	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	0.1111
p.N581Y	DO41903	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	0.25
p.T564K	IST-SL1	lung	COSMIC	PRSST	DEG_SPOP_SBC_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JNW5	UHRF1-binding protein 1-like	DEG_SPOP_SBC_1	1328:1332	PRSST	SPOP	0.9595	More...
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.9128	More...
O00512	B-cell CLL/lymphoma 9 protein	DEG_SPOP_SBC_1	151:155	PRSST	SPOP	0.9984	More...
O94915	Protein furry homolog-like	DEG_SPOP_SBC_1	97:101	PRSST	SPOP	0.926	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	545:549	PRSST	SPOP	0.9681	More...
P48764	Sodium/hydrogen exchanger 3	DEG_SPOP_SBC_1	574:578	PRSST	SPOP	0.807	More...
Q8IZP1	TBC1 domain family member 3	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q8TD19	Serine/threonine-protein kinase Nek9	DEG_SPOP_SBC_1	329:333	PRSST	SPOP	0.8086	More...
Q8WTW3	Conserved oligomeric Golgi complex subunit 1	DEG_SPOP_SBC_1	888:892	PRSST	SPOP	0.8806	More...
Q6DHY5	TBC1 domain family member 3G	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q9Y5G5	Protocadherin gamma-A8	DEG_SPOP_SBC_1	221:225	PRSST	SPOP	0.8172	More...
A6NDS4	TBC1 domain family member 3B	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
A6NER0	TBC1 domain family member 3F	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
P0C7X1	TBC1 domain family member 3H	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9461	More...
Q6IPX1	TBC1 domain family member 3C	DEG_SPOP_SBC_1	410:414	PRSST	SPOP	0.9745	More...
Q9NVM1	Protein eva-1 homolog B	DEG_SPOP_SBC_1	68:72	PRSST	SPOP	0.6927	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	714:718	PRSST	SPOP	0.764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons