DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PRSST
Uniprot ID:
Q8WTW3
Source protein:
Conserved oligomeric Golgi complex subunit 1
Source gene:
COG1
Class:
DEG_SPOP_SBC_1
Location:
888:892
E3 ligase:
SPOP
DEGRON score:
0.8806
ASA_SCORE:
96.44
COIL:
0.877
CONS_SCORE:
0.2815
DSS_SCORE:
0.5768
HELIX:
0.0828
FCONS_SCORE:
0.779
RIG_SCORE:
0.703
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R889W
TCGA-B7-A5TI
STAD
TCGA
PRSST
DEG_SPOP_SBC_1
0.7523
p.R889W
DO222328
STAD
ICGC
PRSST
DEG_SPOP_SBC_1
0.7523
p.H899Q
TCGA-EE-A2GD
SKCM
TCGA
PRSST
DEG_SPOP_SBC_1
0.1389
p.H899Q
DO37603
SKCM
ICGC
PRSST
DEG_SPOP_SBC_1
0.1389
p.R889Q
SIDM00640
Mesothelioma
GDSC
PRSST
DEG_SPOP_SBC_1
0.6218
p.R889Q
ACH-000335
Lung Cancer
CCLE
PRSST
DEG_SPOP_SBC_1
0.6218
p.R889Q
MSTO-211H
pleura
COSMIC
PRSST
DEG_SPOP_SBC_1
0.6218
p.V879M
SIDM00150
Colorectal Carcinoma
GDSC
PRSST
DEG_SPOP_SBC_1
0.0833
p.V879M
ACH-000969
Colon/Colorectal Cancer
CCLE
PRSST
DEG_SPOP_SBC_1
0.0833
p.V879M
KM12
large_intestine
COSMIC
PRSST
DEG_SPOP_SBC_1
0.0833
Drug responses associated with COG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A0JNW5
UHRF1-binding protein 1-like
DEG_SPOP_SBC_1
1328:1332
PRSST
SPOP
0.9595
More...
A6H8Y1
Transcription factor TFIIIB component B'' homolog
DEG_SPOP_SBC_1
68:72
PRSST
SPOP
0.9128
More...
O00512
B-cell CLL/lymphoma 9 protein
DEG_SPOP_SBC_1
151:155
PRSST
SPOP
0.9984
More...
O94915
Protein furry homolog-like
DEG_SPOP_SBC_1
97:101
PRSST
SPOP
0.926
More...
O94929
Actin-binding LIM protein 3
DEG_SPOP_SBC_1
545:549
PRSST
SPOP
0.9681
More...
P48764
Sodium/hydrogen exchanger 3
DEG_SPOP_SBC_1
574:578
PRSST
SPOP
0.807
More...
Q8IZP1
TBC1 domain family member 3
DEG_SPOP_SBC_1
410:414
PRSST
SPOP
0.9461
More...
Q8TD19
Serine/threonine-protein kinase Nek9
DEG_SPOP_SBC_1
329:333
PRSST
SPOP
0.8086
More...
Q8WTW3
Conserved oligomeric Golgi complex subunit 1
DEG_SPOP_SBC_1
888:892
PRSST
SPOP
0.8806
More...
Q6DHY5
TBC1 domain family member 3G
DEG_SPOP_SBC_1
410:414
PRSST
SPOP
0.9461
More...
Q9Y5G5
Protocadherin gamma-A8
DEG_SPOP_SBC_1
221:225
PRSST
SPOP
0.8172
More...
A6NDS4
TBC1 domain family member 3B
DEG_SPOP_SBC_1
410:414
PRSST
SPOP
0.9461
More...
A6NER0
TBC1 domain family member 3F
DEG_SPOP_SBC_1
410:414
PRSST
SPOP
0.9461
More...
P0C7X1
TBC1 domain family member 3H
DEG_SPOP_SBC_1
410:414
PRSST
SPOP
0.9461
More...
Q6IPX1
TBC1 domain family member 3C
DEG_SPOP_SBC_1
410:414
PRSST
SPOP
0.9745
More...
Q9NVM1
Protein eva-1 homolog B
DEG_SPOP_SBC_1
68:72
PRSST
SPOP
0.6927
More...
Q96KW2
POM121-like protein 2
DEG_SPOP_SBC_1
714:718
PRSST
SPOP
0.764
More...