DegronMD - Q8WTW3(COG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R922Q	TCGA-AA-3984	COAD	TCGA	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1944
p.R922Q	DO9002	COAD	ICGC	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1944
p.R922Q	SIDM00534	Colorectal Carcinoma	GDSC	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1944
p.R922Q	ACH-000986	Colon/Colorectal Cancer	CCLE	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1944
p.R922Q	HT-115	large intestine	COSMIC	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1944
p.R889W	TCGA-B7-A5TI	STAD	TCGA	PRSST	DEG_SPOP_SBC_1	888:892	Mutation altering degron motif	0.7523
p.R889W	DO222328	STAD	ICGC	PRSST	DEG_SPOP_SBC_1	888:892	Mutation altering degron motif	0.7523
p.H899Q	TCGA-EE-A2GD	SKCM	TCGA	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.0556
p.H899Q	TCGA-EE-A2GD	SKCM	TCGA	PRSST	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.1389
p.H899Q	DO37603	SKCM	ICGC	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.0556
p.H899Q	DO37603	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.1389
p.R922P	TCGA-EY-A1GS	UCEC	TCGA	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1944
p.R922P	DO43162	UCEC	ICGC	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1944
p.G912V	DO229036	LICA	ICGC	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation altering degron motif	0.6421
p.R910S	DO41056	UCEC	ICGC	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation altering degron motif	0.7427
p.M918V	SIDM01057	Acute Myeloid Leukemia	GDSC	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.3056
p.M918V	GDM-1	haematopoietic and lymphoid tissue	COSMIC	IRFGLLPLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.3056
p.R889Q	SIDM00640	Mesothelioma	GDSC	PRSST	DEG_SPOP_SBC_1	888:892	Mutation altering degron motif	0.6218
p.R889Q	ACH-000335	Lung Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	888:892	Mutation altering degron motif	0.6218
p.R889Q	MSTO-211H	pleura	COSMIC	PRSST	DEG_SPOP_SBC_1	888:892	Mutation altering degron motif	0.6218
p.V879M	SIDM00150	Colorectal Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.0833
p.V879M	ACH-000969	Colon/Colorectal Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.0833
p.V879M	KM12	large intestine	COSMIC	PRSST	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.0833

Kaplan plot for COG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COG1

UniProt ID: Q8WTW3

Entrez ID: 9382

Protein name: Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COG1 in