DegronMD

Uniprot ID: Q8WTW3

Source protein: Conserved oligomeric Golgi complex subunit 1

Source gene: COG1

Class: DEG_APCC_DBOX_1

Location: 909:917

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9979

ASA_SCORE: 47.3111

COIL: 0.7011

CONS_SCORE: 0.4383

DSS_SCORE: 0.3605

HELIX: 0.0701

FCONS_SCORE: 1.2986

RIG_SCORE: 0.7714

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R922Q	TCGA-AA-3984	COAD	TCGA	IRFGLLPLS	DEG_APCC_DBOX_1	0.1944
p.R922Q	DO9002	COAD	ICGC	IRFGLLPLS	DEG_APCC_DBOX_1	0.1944
p.R922Q	SIDM00534	Colorectal Carcinoma	GDSC	IRFGLLPLS	DEG_APCC_DBOX_1	0.1944
p.R922Q	ACH-000986	Colon/Colorectal Cancer	CCLE	IRFGLLPLS	DEG_APCC_DBOX_1	0.1944
p.R922Q	HT-115	large_intestine	COSMIC	IRFGLLPLS	DEG_APCC_DBOX_1	0.1944
p.H899Q	TCGA-EE-A2GD	SKCM	TCGA	IRFGLLPLS	DEG_APCC_DBOX_1	0.0556
p.H899Q	DO37603	SKCM	ICGC	IRFGLLPLS	DEG_APCC_DBOX_1	0.0556
p.R922P	TCGA-EY-A1GS	UCEC	TCGA	IRFGLLPLS	DEG_APCC_DBOX_1	0.1944
p.R922P	DO43162	UCEC	ICGC	IRFGLLPLS	DEG_APCC_DBOX_1	0.1944
p.G912V	DO229036	LICA	ICGC	IRFGLLPLS	DEG_APCC_DBOX_1	0.6421
p.R910S	DO41056	UCEC	ICGC	IRFGLLPLS	DEG_APCC_DBOX_1	0.7427
p.M918V	SIDM01057	Acute Myeloid Leukemia	GDSC	IRFGLLPLS	DEG_APCC_DBOX_1	0.3056
p.M918V	GDM-1	haematopoietic_and_lymphoid_tissue	COSMIC	IRFGLLPLS	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WTW3	Conserved oligomeric Golgi complex subunit 1	DEG_APCC_DBOX_1	909:917	IRFGLLPLS	APC,CDC20,FZR1	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons