DegronMD - A6H8Y1(BDP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P215A	TCGA-05-4250	LUAD	TCGA	PSTPVQT	DEG_SCF_FBW7_1	212:218	Mutation altering degron motif	0.7503
p.E65D	TCGA-06-1802	GBM	TCGA	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.25
p.E65D	DO12100	GBM	ICGC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.25
p.E1895K	TCGA-06-5416	GBM	TCGA	LAPEEVNKAPVFV	DEG_ODPH_VHL_1	1892:1904	Mutation altering degron motif	0.591
p.E206A	TCGA-2W-A8YY	CESC	TCGA	PSTPVQT	DEG_SCF_FBW7_1	212:218	Mutation rewiring degron network	0.1667
p.E206A	TCGA-2W-A8YY	CESC	TCGA	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.2222
p.E206A	DO223732	CESC	ICGC	PSTPVQT	DEG_SCF_FBW7_1	212:218	Mutation rewiring degron network	0.1667
p.E206A	DO223732	CESC	ICGC	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.2222
p.R2067S	TCGA-64-1680	LUAD	TCGA	VKENA	DEG_APCC_KENBOX_2	2076:2080	Mutation rewiring degron network	0.0833
p.E1374Q	TCGA-66-2773	LUSC	TCGA	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.1944
p.E1374Q	DO26536	LUSC	ICGC	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.1944
p.M199R	TCGA-85-8071	LUSC	TCGA	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation altering degron motif	0.7521
p.M199R	DO26755	LUSC	ICGC	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation altering degron motif	0.7521
p.S2088F	TCGA-A5-A0G2	UCEC	TCGA	VKENA	DEG_APCC_KENBOX_2	2076:2080	Mutation rewiring degron network	0.1111
p.D80Y	TCGA-A5-A2K5	UCEC	TCGA	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1111
p.D80Y	DO41379	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1111
p.N1289S	TCGA-AA-3519	COAD	TCGA	GKENF	DEG_APCC_KENBOX_2	1286:1290	Mutation altering degron motif	0.7069
p.N1289S	DO7914	COAD	ICGC	GKENF	DEG_APCC_KENBOX_2	1286:1290	Mutation altering degron motif	0.7069
p.V216D	TCGA-AJ-A3EK	UCEC	TCGA	PSTPVQT	DEG_SCF_FBW7_1	212:218	Mutation altering degron motif	0.6674
p.V216D	DO41584	UCEC	ICGC	PSTPVQT	DEG_SCF_FBW7_1	212:218	Mutation altering degron motif	0.6674
p.E1288K	TCGA-AX-A05Z	UCEC	TCGA	GKENF	DEG_APCC_KENBOX_2	1286:1290	Mutation altering degron motif	0.7022
p.E1288K	DO40884	UCEC	ICGC	GKENF	DEG_APCC_KENBOX_2	1286:1290	Mutation altering degron motif	0.7022
p.S71I	TCGA-BF-A1PZ	SKCM	TCGA	PRSST	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7341
p.E1912A	TCGA-BR-4191	STAD	TCGA	LAPEEVNKAPVFV	DEG_ODPH_VHL_1	1892:1904	Mutation rewiring degron network	0.1111
p.K1375R	TCGA-CJ-4636	KIRC	TCGA	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation substituting flanking lysine	0.2778
p.K1375R	DO19298	KIRC	ICGC	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation substituting flanking lysine	0.2778
p.E1296K	TCGA-DK-AA76	BLCA	TCGA	GKENF	DEG_APCC_KENBOX_2	1286:1290	Mutation rewiring degron network	0.1667
p.E1296K	DO219013	BLCA	ICGC	GKENF	DEG_APCC_KENBOX_2	1286:1290	Mutation rewiring degron network	0.1667
p.S2050C	TCGA-DR-A0ZM	CESC	TCGA	VITTS	DEG_SPOP_SBC_1	2046:2050	Mutation altering degron motif	0.8652
p.I2087L	TCGA-DU-6392	LGG	TCGA	VKENA	DEG_APCC_KENBOX_2	2076:2080	Mutation rewiring degron network	0.1389
p.E1374K	TCGA-E5-A4U1	BLCA	TCGA	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.1944
p.E1374K	DO44061	BLCA	ICGC	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.1944
p.R1371I	TCGA-F5-6814	READ	TCGA	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.2778
p.R1371I	DO36556	READ	ICGC	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.2778
p.E1368Q	TCGA-IR-A3LA	CESC	TCGA	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation altering degron motif	0.5633
p.E1368Q	DO44377	CESC	ICGC	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation altering degron motif	0.5633
p.S2043F	TCGA-Z2-A8RT	SKCM	TCGA	VITTS	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.25
p.E198Q	DO224650	BRCA	ICGC	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation altering degron motif	0.6744
p.M59I	DO7962	COAD	ICGC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.I195V	DO230323	COCA	ICGC	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.T222A	DO234424	ESAD	ICGC	PSTPVQT	DEG_SCF_FBW7_1	212:218	Mutation rewiring degron network	0.2222
p.P194S	DO11854	GBM	ICGC	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.2222
p.I223L	DO22237	LGG	ICGC	PSTPVQT	DEG_SCF_FBW7_1	212:218	Mutation rewiring degron network	0.1944
p.M59V	DO23210	LINC	ICGC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.M59V	DO23274	LINC	ICGC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.S1378L	DO231782	LINC	ICGC	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.0833
p.R203S	DO24646	LUAD	ICGC	PSTPVQT	DEG_SCF_FBW7_1	212:218	Mutation rewiring degron network	0.0833
p.R203S	DO24646	LUAD	ICGC	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.3056
p.E63Q	DO27074	LUSC	ICGC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1944
p.E198K	DO232761	PBCA	ICGC	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation altering degron motif	0.7022
p.P82Q	DO50279	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0556
p.P69Q	DO47636	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7035
p.V77A	DO229272	THCA	ICGC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1944
p.A188T	DO229275	THCA	ICGC	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0556
p.L197F	DO229232	THCA	ICGC	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.3056
p.P69A	DO40526	THCA	ICGC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7503
p.S224F	DO41235	UCEC	ICGC	PSTPVQT	DEG_SCF_FBW7_1	212:218	Mutation blocking ubiquitination signal	0.6111
p.E1277Q	SIDM02040	Esophageal Carcinoma	GDSC	GKENF	DEG_APCC_KENBOX_2	1286:1290	Mutation rewiring degron network	0.0833
p.S2044L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VITTS	DEG_SPOP_SBC_1	2046:2050	Mutation blocking phosphorylation signal	0.7222
p.S2044L	ACH-000924	Lung Cancer	CCLE	VITTS	DEG_SPOP_SBC_1	2046:2050	Mutation blocking phosphorylation signal	0.7222
p.S2044L	NCI-H2172	lung	COSMIC	VITTS	DEG_SPOP_SBC_1	2046:2050	Mutation blocking phosphorylation signal	0.7222
p.E1358D	SIDM00600	Thyroid Gland Carcinoma	GDSC	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.2222
p.E1358D	SIDM01451	Pancreatic Carcinoma	GDSC	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.2222
p.E1358D	IHH-4	thyroid	COSMIC	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.2222
p.S71N	SIDM00516	Melanoma	GDSC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7069
p.S71N	MZ7-mel	skin	COSMIC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7069
p.E2056K	SIDM01052	Ovarian Carcinoma	GDSC	VITTS	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.1667
p.E2056K	ACH-000308	Ovarian Cancer	CCLE	VITTS	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.1667
p.E2056K	EFO-21	ovary	COSMIC	VITTS	DEG_SPOP_SBC_1	2046:2050	Mutation rewiring degron network	0.1667
p.S1357R	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.1944
p.S1357R	ACH-001489	Lung Cancer	CCLE	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.1944
p.S1357R	COR-L32	lung	COSMIC	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation rewiring degron network	0.1944
p.M199T	SIDM01608	Endometrial Carcinoma	GDSC	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation altering degron motif	0.6312
p.M199T	ACH-000990	Endometrial/Uterine Cancer	CCLE	PMTSS	DEG_SPOP_SBC_1	198:202	Mutation altering degron motif	0.6312
p.E65K	SIDM00158	Glioblastoma	GDSC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.25
p.D1884G	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPEEVNKAPVFV	DEG_ODPH_VHL_1	1892:1904	Mutation rewiring degron network	0.1111
p.E62K	SIDM00500	Colorectal Carcinoma	GDSC	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1667
p.E62K	ACH-000959	Colon/Colorectal Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1667
p.V1367A	SIDM01588	Endometrial Carcinoma	GDSC	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation altering degron motif	0.5825
p.V1367A	ACH-000993	Endometrial/Uterine Cancer	CCLE	MMHTPVEE	DEG_SCF_FBW7_2	1362:1369	Mutation altering degron motif	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BDP1

UniProt ID: A6H8Y1

Entrez ID: 55814

Protein name: Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BDP1 in